RESPONSE TO ANTICONVULSANTS IN JUVENILE BIPOLAR DISORDER AS MEASURED BY MRS

1. 神经胶质瘤患者多模态数据库的建立 a）对脑肿瘤进行编目和存档 不同患者的冷冻样本。 或按时间顺序排列， 多个样本的患者，并将原始病理 通过H和E染色诊断和组织学特征， 免疫组化 B）。 基因表达谱的分类 使用互补DNA阵列的冷冻脑肿瘤样品。 c）、 将诊断、年龄、功能、 状态、存活率和对治疗的反应。 d）阳离子线成像 提供对治疗的反应和表征成像的数据 模式. I胶质瘤基因表达模式分类的发展， 提供更好的生存预测：a）在组织病理学范围内， B）级超出组织病理学拉德 3. 定义有助于预测反应的基因表达模式， 不同治疗方法对骨肉瘤患者预后的影响 包括. surgen-，辐射。 化疗，生物治疗， 免疫疗法

1. Development of a multimodality database for glionia patients with the following domains: a) cataloging and archiving brain tumor frozen samples in different patients. or chronologically in the same patients with multiple samples, and cataloging the firial pathologic diagnosis, and histologic characteristics through H and E stains and immunohistochemistry . b). cataloging gene expression profiles of frozen brain tumor samples using complementary DNA array . c) cataloging clinical information regarding diagnosis, age, functional status, survival and response to treatment. d) cataio-ine imaging data providing response to treatment and to characterize imaging patterns . I Deveiopment of gene expression pattern classification in gliomas to provide better prediction of survival: a) within histopathologic grade b) outside histopathologic --rade 3. Define gene expression pattern that will help predict response and prognosis in patients with ghoma treated with various therapies including. surgen-, radiation. chemotherapy, biologic therapy, immunotherapy.