CORE--TRANSFECTION VECTOR

矢量核心将支持所有的个人项目， 应用程序. 载体核心将使高纯度和良好的 为研究者的研究项目提供腺病毒载体。 这些 病毒包括bcl-xs腺病毒、hrk腺病毒和mbm-2 腺病毒。 这些病毒将用于基础研究， 癌细胞中的程序性细胞死亡途径， 乳腺卵巢膀胱和造血细胞 这些病毒 也将用于动物模型，以测试这些 病毒作为基因治疗剂。 最后，bcl-xs腺病毒将 用于乳腺癌的临床试验， 卵巢癌

The vector core will support all of the individual projects in this application. The vector core will make highly purified and well characterized adenovirus vectors for the investigator's projects. These viruses include a bcl-xs adenovirus, a hrk adenovirus, and an mbm-2 adenovirus. These viruses will be used in basic studies to analyze the programmed cell death pathways in cancer cells that arise from the breast, the ovaries, the bladder and hematopoietic cells. These viruses will also be used in animal models to test the potential of these viruses as gene therapy agents. Finally, the bcl-xs adenovirus will be produced by this vector core for clinical trials in breast cancer and ovarian cancer.