MULTIPHOTON DOSE DERIVATION

在过去的一年里，我们已经完成了对 Photofrin的双光子作用截面，并已开始 其它光敏化合物的附加测量。 下 在典型的成像条件下，观察到Photofrin从 单光子到双光子激发，因为激发波长是 范围为700-750 nm。 这已经通过测量边缘得到了验证 来自Photofrin溶解在甲醇中的溶液的响应， 波长的函数 对于750和980 nm之间的波长， 双光子作用截面从大约0.6 GM减小到 0.2 GM. 绝对和相对横截面测量都具有 被发现并同意。 双光子激发截面 其他光敏剂正处于不同的完成阶段， 在别处描述和说明。

During the previous year we have completed the measurement of the two-photon action cross section for Photofrin and have begun additional measurements for other photosensitizing compounds. Under typical imaging conditions, Photofrin is observed to change from one-photon to two-photon excitation as the excitation wavelength is varied from 700-750 nm. This has been verified by measuring the edge response from a solution of Photofrin dissolved in methanol as a function of wavelength. For wavelengths between 750 and 980 nm the two-photon action cross section decreases from approximately 0.6 GM to 0.2 GM. Both absolute and relative cross section measurements have been made and found to agree. The two-photon excitation cross section of other photosensitizers are at various stages of completion and described and accounted for elsewhere.