PRESENTATIONS BY G ALLAN JOHNSON, PH D: MR MICROSCOPY & 3 D VISUALIZ

膝关节半月板的损伤或损伤导致进行性 关节软骨的退化，其特征在于 骨关节炎 我们建议，一种由以下物质构建的自体血管移植物 髂胫筋膜将抑制膝关节软骨退化 切除后。 在这个为期24个月的拟议项目中，我们计划 量化犬膝关节切除术后的以下情况 （n=15）和自体移植物植入后（n=15）：（1）机械性 关节软骨的性质;（2） （3）原生和再生体的三维几何形状 半月板的MR显微镜检查。 在这种情况下，我们将比较 软骨退变状态和关节功能参数 和解剖学，以区分“未治疗”和“治疗” 外科手术组。 长期目标是发展量化 评价所提出的自体尿道移植物的功效的方法， 以及其它外科治疗（例如，同种异体移植物）， 膝关节骨关节炎。 实验证明， 成功地抑制变性的治疗， 动物模型将促进临床治疗的选择。

Damage or injury of the knee meniscus leads to progressive degeneration of articular cartilage in which is characteristic of osteoarthritis. We propose that a meniscal autograft constructed from iliotibial fascia will inhibit cartilage degeneration in the knee following meniscectomy. In this 24-month proposed project, we plan to quantify the following in the canine knee following meniscectomy (n=15), and following autograft implantation (n=15): (1) mechanical properties of articular cartilage; (2) material properties of regenerate menisci; and (3) the 3-D geometry of native and regenerate meniscus using MR microscopy. In this manner, we will compare the state of cartilage degeneration, and parameters of meniscal function and anatomy, for differences between "untreated" and "treated" surgical groups. The long-term objectives are to develop quantitative methods to evaluate the efficacy of the proposed meniscal autograft, as well as other surgical treatments (e.g., allograft) for preventing osteoarthritis in the knee joint. Experimental evidence of such treatments which are successful for inhibiting degeneration in an animal model would promote options for clinical treatment.