Clinical Outcomes in Rehabilitated Burn Children

该建议将检验以下假设：运动计划和每日给予重组人生长激素将促进严重烧伤后儿童完全恢复生理功能。将进行一项干预研究，其中将在烧伤后长达一年的时间内每隔3个月对临床相关结局参数进行量化。一半患者将被随机分配至全年接受0.05 mg/kg/d重组人生长激素或安慰剂注射。每组将进一步随机参加Shriners Burns医院提供的为期3个月的运动调节计划，或接受标准的家庭康复。因此，将对4组患者进行烧伤后长达一年的研究。本研究的终点将是膝关节高度和站立高度、体重、通过40 K计数器和双能X线吸收测定法（DEXA）测定的瘦体重、肌力、骨密度、骨组织形态计量学和通过温哥华瘢痕量表测定的瘢痕形成。还将从皮肤活检中进行III、IV和VII型胶原蛋白的鉴定和定量。

This proposal will test the hypothesis that an exercise program and the daily administration of recombinant human growth hormone will promote recovery to full physiological function in children after severe burn injury. An intervention study will be performed in which clinically relevant outcome parameters will be quantified at 3-month intervals up to one year post-burn. Half of the patients will be randomized to receive 0.05 mg/kg/d of recombinant human growth hormone or placebo injection throughout the year. Each group will be further randomized to participate in a 3-month exercise-conditioning program offered at the Shriners Burns Hospital, or receive standard home rehabilitation. Thus, 4 groups of patients will be studied up to one year post-burn. Endpoints of this study will be knee heights and standing height, body weight, lean body mass determined by 40K-counter and dual energy x-ray absorptiometry (DEXA), muscle strength, bone density, bone histomorphometry, and scar formation by the Vancouver Scar Scale. Identification and quantitation of types III, IV, and VII collagen will also be made from skin biopsies.