RES FACIL CONSTRUCTION: BREAST CANCER

描述（由申请人提供）：NYSBC是一个由9个学术医学研究机构组成的联合体，拟建设一个10000平方米的医学研究中心。除了现有的设施外，还将容纳三个最先进的冷冻EM。目标是通过在冷冻EM的互补领域创建资源和计划，扩大NYSBC的科学范围，目前专注于磁共振光谱。国际公认的美国国立卫生研究院（NIH）资助的生物学家社区，目前没有足够的（或任何）机构访问冷冻EM。拟议的扩展将为超过25个直接使用冷冻EM或结合晶体学和磁共振波谱学来研究蛋白质和超分子机器的研究小组提供服务。另外40名目前不使用低温EM的研究人员将能够利用扩展后的NYSBC提供的综合资源，在他们的领域中承担更困难的问题。nybc位于曼哈顿上城133街和Convent大道的纽约城市学院（CCNY）校园内。它将分三期建设：1)第一期和第二期将安装一组高场磁共振光谱仪（750、800和900兆赫）；第一期工程将于2002年3月31日开始运作；第二期工程将于二零零二年十二月三十一日前投入运作。此申请只适用于第三期拨款。它占地1万平方英尺。用于容纳3台120千伏、200千伏和300千伏的低温电磁设备，以及必要的辅助活动。

DESCRIPTION (provided by applicant): The NYSBC, a consortium of nine academic medical research institutions, proposes to construct a 10,000 sq. ft. addition to its existing facilities to house three state-of-the-art cryo EM. The objective is to expand the NYSBC's scientific scope, which currently focuses on magnetic resonance spectroscopy, by creating a resource and program in the complementary field of cryo EM. These new resources will serve a large, internationally-recognized community of National Institutes of Health (NIH)-funded biologists who do not currently have adequate (or any) institutional access to cryo EM. The proposed expansion will serve more than 25 research groups that use cryo EM directly, or in conjunction with crystallography and magnetic resonance spectroscopy, to study proteins and supramolecular machines. Another 40 researchers who do not currently use cryo EM, will be able to undertake more difficult problems in their fields with access to the integrated resources provided by the expanded NYSBC. The NYSBC is located on the campus of City College of New York (CCNY) at 133rd Street and Convent Avenue in Upper Manhattan. It is being constructed in three phases: 1) Phases I and II will house a group of high-field magnetic resonance spectrometers (750, 800 and 900 at MHz); Phase I will be operational by March 31, 2002; and Phase II will be operational by December 31, 2002. This application is for Phase III funding only. It comprises 10,000 sq. ft. to house three cryo EM at 120 kV, 200 kV, and 300 kV, and necessary ancillary activities.