BIOMED RES FACIL: AD DEMENTIA

描述(由申请人提供)：本申请建议建造程序和行为住房套房(PBHS)，面积为5,215平方米。英国《金融时报》加州大学欧文医学院BRC中的扩张。BRC部分完工并正在分阶段建设，计划为四栋建筑，占地20万平方米。英国《金融时报》致力于神经科学、癌症、遗传学、免疫学和传染病等领域的跨学科研究的综合体。现有教员和正在招聘的教员的生物医学研究在很大程度上依赖于动物研究，这就迫切需要为PBHS增加空间。该项目将扩大现有的12,320平方米。英国《金融时报》并将地下隔间建筑群与BRC的四座大楼(一座投入使用，两座在建，一座规划中)连接起来。PBHS将由三个套房组成，每个套房都有效地结合了三种基本类型的房间：1)程序室；2)行为测试室；3)啮齿动物等待室。该建筑还将包括一个较小的三个房间的吉莱斯皮·维瓦利姆扩建项目(一个住房房间，一个行为测试室和一个接待室)。程序和行为测试室的设计允许改装成动物收容所或测试和程序室的不同组合。如果需要，有一个建筑选项可以将一个或多个套房转换为屏障设施。临时程序和测试室将被释放，以恢复其最初的动物收容所用途。该应用程序确定了一群由PHS资助的教职员工，他们将利用PBHS在对国家健康重要的领域推广生物医学知识。

DESCRIPTION (provided by applicant): This application proposes construction of the Procedural and Behavioral Housing Suites (PBHS), a 5,215 sq. ft. vivarium expansion in the BRC at the UC- Irvine College of Medicine. Partially completed and under phased construction, the BRC is planned as a four building, 200,000 sq. ft. complex dedicated to interdisciplinary research in the areas of neuroscience, cancer, genetics, immunology, and infectious disease. Biomedical research by current faculty and those under recruitment relies heavily on animal research, creating an urgent need to increase vivarium space for PBHS. The project would expand the existing 12,320 sq. ft. Gillespie Vivarium and connect the underground vivarium complex to the four BRC buildings (one operational, two under construction, and one planned). The PBHS would consist of three suites, each efficiently combining rooms of three basic types: 1) procedure rooms; 2) behavioral testing rooms; and 3) rodent holding rooms. The construction also would include a smaller three-room Gillespie Vivarium Extension (one housing room, one behavioral testing room, and an anteroom). The procedure and behavioral testing rooms have been designed to allow conversion into animal housing or a different mix of testing and procedure rooms. There is an architectural option to convert one or more of the suites into barrier facilities if need arises. Temporary procedure and testing rooms would be released to revert to their original purpose of animal housing. The application identifies a group of PHS-funded faculty members who would use the PBHS to advance biomedical knowledge in areas important to the nation's health.