BIOMED RES FACIL: CANCER

描述（由申请人提供）：本申请提议建造程序和行为住房套房（PBHS），占地5,215平方米。加州大学欧文分校医学院BRC的试管扩张。BRC部分完工，正在分期建设中，规划为四座建筑，200,000平方英尺。致力于神经科学、癌症、遗传学、免疫学和传染病领域的跨学科研究。现有教员和正在招聘的教员的生物医学研究在很大程度上依赖于动物研究，因此迫切需要增加PBHS的动物实验空间。该项目将扩大现有的12320平方英尺。并将地下Vivarium综合体与BRC的四座建筑（一座正在运营，两座正在建设，一座正在规划）连接起来。PBHS将由三间套房组成，每间套房有效地结合了三种基本类型的房间：1)手术室；2)行为试验室；3)啮齿动物饲养室。该建筑还将包括一个较小的三室吉莱斯皮Vivarium扩建（一个住房室，一个行为测试室和一个接待室）。程序和行为检测室的设计允许转换为动物住房或不同的混合测试和程序室。如果需要，有一个架构选项可以将一个或多个套房转换为屏障设施。临时程序和测试室将被释放，以恢复其最初的动物住房用途。该申请确定了一组由PBHS资助的教师，他们将利用PBHS在对国家健康重要的领域推进生物医学知识。

DESCRIPTION (provided by applicant): This application proposes construction of the Procedural and Behavioral Housing Suites (PBHS), a 5,215 sq. ft. vivarium expansion in the BRC at the UC- Irvine College of Medicine. Partially completed and under phased construction, the BRC is planned as a four building, 200,000 sq. ft. complex dedicated to interdisciplinary research in the areas of neuroscience, cancer, genetics, immunology, and infectious disease. Biomedical research by current faculty and those under recruitment relies heavily on animal research, creating an urgent need to increase vivarium space for PBHS. The project would expand the existing 12,320 sq. ft. Gillespie Vivarium and connect the underground vivarium complex to the four BRC buildings (one operational, two under construction, and one planned). The PBHS would consist of three suites, each efficiently combining rooms of three basic types: 1) procedure rooms; 2) behavioral testing rooms; and 3) rodent holding rooms. The construction also would include a smaller three-room Gillespie Vivarium Extension (one housing room, one behavioral testing room, and an anteroom). The procedure and behavioral testing rooms have been designed to allow conversion into animal housing or a different mix of testing and procedure rooms. There is an architectural option to convert one or more of the suites into barrier facilities if need arises. Temporary procedure and testing rooms would be released to revert to their original purpose of animal housing. The application identifies a group of PHS-funded faculty members who would use the PBHS to advance biomedical knowledge in areas important to the nation's health.