RES BLDG RENOVATION: DIABETES

描述（由申请人提供）：Schepens眼科研究所打算翻新其64，000平方米。英尺实验室大楼建于40年前。该计划的目标是提供现代化的实验室和支持设施，使个别科学家，单独和合作，与强大的现代科学学科的疾病病理学问题，没有预防或治疗现在存在攻击。改造计划包括两个阶段;第一阶段正在进行中，旨在重建大楼的基础设施，包括供暖、通风和空调（HVAC）、管道和电力系统等。英尺每一个）在三个连续的段中。第一和第二部分是2000年资助的上一个应用程序的主题，其目标是为14名主要研究者（PI）在三个单独的楼层上翻新实验室，研究活动包括眼部免疫，炎症和移植（二楼北），眼表疾病（三楼）和视网膜生物学（一楼北）。作为当前申请的主题的区段3a的目标是翻新约10，000平方米的建筑面积。英尺位于实验楼南面二楼的一个面积为1000平方米的实验室，为四位主要从事眼部免疫、炎症和移植研究的专业研究人员提供高质量的实验室。完成后，研究所所有从事免疫、炎症和移植工作的研究人员将位于二楼。此外，翻新后的区域将包括：1）一个新的分子生物学核心设施; 2）一个玻璃器皿清洗设施; 3）一个会议室和通讯中心。第3a部分的费用总额为390万美元，要求提供约180万美元。一旦第3a段完成，将有空间进行第3b段。翻修计划完成后，研究所将有一个足以满足目前研究需要的物理设施。

DESCRIPTION (Provided by applicant): The Schepens Eye Research Institute intends to renovate its 64,000 sq. ft. laboratory building built approximately 40 years ago. The goal of this program is to provide modern laboratories and support facilities to enable individual scientists, alone and in collaborations, to attack with powerful modern scientific disciplines the problems of disease pathology for which no prevention or cure now exists. The renovation program consists of two phases; the first of which is underway and is designed to reconstruct the building's infrastructure heating, ventilation, and air-conditioning (HVAC); plumbing; and electricity systems; etc. The second phase is designed to renovate the three laboratory floors (16,000 sq. ft. each) in three sequential segments. Segments one and two, which were the subject of the previous application that was funded in 2000, had the goal of renovating laboratories on three separate floors for 14 Principal Investigators (PIs) with research activities in ocular immunity, inflammation and transplantation (Second Floor North), ocular surface diseases (Third Floor), and biology of the retina (First Floor North). Segment 3a, which is the subject of the current application, has the goal of renovating approximately 10,000 sq. ft. of space on the second floor South of laboratory building in order to provide high quality laboratories for four PIs whose research focus is ocular immunity, inflammation and transplantation. Upon completion, all investigators at the Institute working in immunity, inflammation and transplantation will be located on the second floor. In addition, the renovated area will include: 1) a new molecular biology core facility; 2) a glassware washing facility; and 3) a conference room and communication center. Approximately $1.8 million toward a total cost of $3.9 million for Segment 3a is requested. Once Segment 3a is accomplished, space will be available to carry out Segment 3b. At the completion of the renovation program, the Institute will have a physical facility sufficient to meet present research needs.