CENTER FOR REPRODUCTIVE SCIENCES

堪萨斯大学的生殖和发育生物学家 医学中心提出了一个基础研究P30中心，专注于主题 与生育和不育有关。 该中心将由保罗 F. Terranova，生理学和妇产科教授，以及 副主任将是吉尔伯特S。格林沃尔德，杰出教授 生理学。 主要研究者及其研究兴趣 Glen Andrews，金属硫蛋白基因的结构/调控， 着床前细胞因子/生长因子的转录调控 胚胎发育生长因子的表达和调节 在围着床期子宫和胚胎中;乔治 Enders，精子发生过程中的细胞相互作用，包括 生精细胞粘附分子的鉴定 Hunt，母体和胚外细胞之间的免疫相互作用 促进生育能力;今川和彦，蛋白质的鉴定 参与母亲对怀孕的识别;威廉·金赛，信号 在受精时的转导事件， 受体酪氨酸蛋白激酶类 催乳素基因的神经内分泌调节机制 表达和催乳素分泌; Michael Soares，滋养层的控制 新的催乳素样蛋白的鉴别和鉴定 胎盘细胞表达;约瑟夫·塔什，基本生化机制 调节精子鞭毛运动，主要侧重于蛋白质 卵巢肿瘤坏死因子的作用 卵巢细胞生长、分化和发育中的α 催乳素分泌的神经化学调节及其影响 催乳素和多巴胺的分泌。 核心实验室 和（董事）是：细胞培养核心（琼亨特）提供高 用于细胞培养和管理常用细胞的高质量/低成本试剂 线 图像分析/摄影核心（约瑟夫塔什）提供生产 以及与原位杂交相关的图像分析， 放射自显影、免疫细胞化学和组织学。 转基因核心（S.K. Dey）生产转基因动物，并管理各种 转基因株系 一个新的程序开发项目由迈克尔沃尔夫， 生理学助理教授，题为“转录调控的 促性腺激素β亚单位在发育过程中和激素”也是 包括在内，并将扩大和补充现有的研究，在分子 生物学 总之，这个中心将是一个非常刺激的 促进生殖健康领域高质量基础研究的环境 以理工科为重

Reproductive and developmental biologists at the University of Kansas Medical Center propose a Basic Research P30 Center that focuses on topics related to fertility and infertility. The Center will be directed by Paul F. Terranova, Professor of Physiology and Obstetrics & Gynecology, and the Associate Director will be Gilbert S. Greenwald, Distinguished Professor of Physiology. The primary investigators and their research interests are: Glen Andrews, structure/regulation of the metallothionein gene and transcriptional control of cytokines/growth factors in preimplantation embryo development; S.K. Dey, expression and regulation of growth factors in the uterus and embryo during the peri-implantation period; George Enders, cellular interactions during spermatogenesis including identification of cell adhesion molecules on spermatogenic cells; Joan Hunt, immunologic interactions between maternal and extraembryonic cells that promote fertility; Kazuhiko Imakawa, identification of proteins involved in the maternal recognition of pregnancy; William Kinsey, signal transduction events at fertilization with specific interest in non- receptor tyrosine protein kinases; Girish Shah, cellular and molecular mechanisms associated with neuroendocrine regulation of prolactin gene expression and prolactin secretion; Michael Soares, control of trophoblast differentiation and identification of novel prolactin-like proteins expressed by placental cells; Joseph Tash, basic biochemical mechanisms regulating sperm flagellar movement with a major emphasis on protein phosphorylation; Paul Terranova, role of ovarian tumor necrosis factor- alpha in growth, differentiation and development of ovarian cells; James Voogt, neurochemical regulation of prolactin secretion and the influence of aging on secretion of prolactin and dopamine. The Core laboratories and (Directors) are: Cell Culture Core (Joan Hunt) provides high quality/low cost reagents for cell culture and manages commonly used cell lines. Image Analysis/Photography Core (Joseph Tash) provides production and analysis of images associated with in situ hybridization, autoradiography, immunocytochemistry and histology. Transgenic Core (S.K. Dey) produces transgenic animals and manages the breeding of various transgenic lines. A New Program Development Project by Michael Wolfe, Assistant Professor of Physiology, entitled "Transcriptional Regulation of Gonadotropin beta Subunits During Development and by Hormones" is also included and will expand and complement existing research in molecular biology. In summary, this center will be an extremely stimulating environment that fosters high quality basic research in the reproductive sciences.