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QUANTIFYING HIV 1 RNA IN CEREBROSPINAL FLUID & BLOOD

QUANTIFYING HIV 1 RNA IN CEREBROSPINAL FLUID & BLOOD
定量脑脊液中的 HIV 1 RNA
批准号：
6308605
负责人：
ANN PETRU
金额：
$1.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6308605
关键词：
AIDS /HIV neuropathy blood chemistry cerebrospinal fluid child (0-11) clinical research genetic strain human immunodeficiency virus 1 human tissue latent virus infection pediatric AIDS virus RNA virus load

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中文摘要
翻译
该方案的假设是，感染该病毒的婴儿和儿童中枢神经系统(CNS)中HIV-1病毒载量的增加将与较差的神经结局相关。此外，我们还将研究，随着越来越多的儿童接受具有不同程度中枢神经系统渗透的抗逆转录病毒药物的联合治疗，中枢神经系统将成为病毒的储存库，来自中枢神经系统的病毒RNA将具有不同于从外周血液分离的病毒的耐药模式。我们还提出，从HIV脑病儿童脑脊液中分离到的病毒与从神经学无症状儿童脑脊液中分离到的病毒在基因上是不同的。
英文摘要
The hypothesis of this protocol is that increases in HIV-1 viral load in the central nervous system (CNS) of infants and children infected with the virus will be associated with a poor neurological outcome. Also, we will examine that as more children receive combination therapy with antiretrovirals that have varying degrees of CNS penetration, the CNS will act as a reservoir for virus and viral RNA from the CNS will have different resistance patterns than isolates from the peripheral blood. We also propose that virus isolated from the CSF of children with HIV encephalopathy is genetically different from virus in the CSF of neurologically asymptomatic children.
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