DYNAMIC CARDIAC SPECT IMAGING

动态心脏单光子发射计算机的研制 断层扫描（SPECT）有可能提供一个敏感的措施， 缺血和表征存活心肌， 成像全医疗设备，具有成像全 可用的心脏放射性药物的医疗设备。动态 心脏SPECT有可能获得更多， 比静态研究更好的诊断信息，无需额外费用 除了计算处理之外。 假设放射性示踪剂的药代动力学估计值 比视觉判读更敏感的心脏病测量 静态图像。拟议的工作将制定处理方法， ~（99）m/Tc-teboroxime和~（201）/Tl-Tc-teboroxime在犬心脏的动态SPECT数据 模特和病人动态心脏SPECT使用单和多- 探测器SPECT系统将用于开发新的算法 其重建生理动力学模型参数的3D图像 没有伪影的心脏动态采集断层扫描 项目实现了以下几个方面：（1）迭代开发 和直接矩阵求逆算法重建动态SPECT 数据(2)动力学模型估计算法的发展 参数直接来自投影测量。(3)发展 感兴趣区域的自动分割和时间的生成 血液、心肌和背景组织的活动曲线。(4)一个 SPECT物理学和人体生理学对偏倚的影响分析 和估计的动力学参数的方差。(5)发展 使用估计的缺血和存活心肌的灵敏测量 99 m/Tc-替硼肟和201/Tl. 拟议的工作将开发应用数学工具， 精确量化动力学参数，系统评估 这些方法与计算机模拟，犬实验， 临床研究。该提案的目标是制定方法， 使用现有的单探测器和多探测器SPECT系统;在此过程中， 使动态SPECT即使在那些只有单一- 探测器SPECT系统，并因此不能执行快速 收购。开发的技术将提供更好的医疗保健 通过更好地检测心肌梗死， 缺血性心脏病，更好地评估组织活力 而不会产生SPECT程序的额外费用。的许多方法 开发的也将适用于成像心肌与葡萄糖 类似物如18FDG和脂肪酸如123 IPPA。是 预计这些技术将适用于成像其他 器官系统，如肾脏和大脑。

The development of dynamic cardiac single photon emission computed tomography (SPECT) has the potential to offer a sensitive measure of ischemia and to characterize viable myocardium with a versatility of imaging the full armamentarium with versatility of imaging the full armamentarium of available cardiac radio-pharmaceuticals. Dynamic cardiac SPECT holds forth the potential of acquiring more and perhaps better diagnostic information than static studies at no additional cost aside from computational processing. The hypothesis is that estimates of pharmacokinetics of radiotracers are more sensitive measures of cardiac disease than visual interpretations of static images. The proposed work will develop methods of processing dynamic cardiac SPECT data of 99m/Tc-teboroxime and 201/Tl in canine models and patients. Dynamic cardiac SPECT using single- and multi- detector SPECT systems will be used in development of new algorithms that reconstruct 3D images of the physiological kinetic model parameters of the heart without artifacts from dynamically acquired tomographic projects. The following will be achieved: (1) Development of iterative and direct matrix inverse algorithms for reconstructing dynamic SPECT data. (2) Development of algorithms for estimating kinetic model parameters directly from projection measurements. (3) Development of automatic segmentation of regions of interest and generation of time activity curves for blood, myocardial, and background tissue. (4) An analysis of effects of SPECT physics and human physiology on the bias and variance of estimated kinetic parameters. (5) Development of a sensitive measure of ischemic and viable myocardium using estimated kinetic parameters of 99m/Tc-teboroxime and 201/Tl. The proposed work will develop applied mathematical tools to accurately and precisely quantify kinetic parameters and systematically evaluate these methods with computer simulations, canine experiments, and clinical studies. The goal of this proposal is to develop methods that use existing single- and multi-detector SPECT systems; and, in so doing, make dynamic SPECT useful even in those clinics which have only single- detector SPECT systems and are thus not able to perform rapid acquisitions. The developed techniques will provide improved health care through better detectability of myocardial infarcts, better diagnosis of ischemic heart disease, and better evaluation of tissue viability without additional cost for the SPECT procedure. Many of the methods developed will also be applicable to imaging the myocardium with glucose analogues such as 18FDG and fatty acids such as 123IPPA. It is anticipated that these techniques will be applicable to imaging other organ systems such as the kidney and the brain.