RESEARCH TRAINING IN AGING CARDIOVASCULAR PHYSIOLOGY

这一职业生涯中期以患者为导向的研究奖的具体目标 是：1)进一步确立候选人的独立病人- 面向衰老神经体液机制的临床研究计划 心血管生理学，20为应聘者提供时间和 为临床实习生提供指导所需的资源 老年心血管生理学的研究。这位候选人有一个 连续资助的患者生产性调查记录- 从团契培训开始就有针对性的研究 从1985年的老年医学到现在。候选人的病人- 定向研究计划资助的是同情者的作用 神经系统(SNS)等神经体液系统在调节 正常人衰老时的血压和心脏收缩能力，以及 患有高血压和心力衰竭的老年患者。受保护的时间 这一奖项提供的资金将允许候选人进一步发展 评估SNS活性调节的新方法--肾上腺素能 老年患者的受体功能和其他神经体液机制 患有高血压和心力衰竭。候选人已经有了一个既定的 为博士后和博士后实习生提供指导的记录。这个 候选人的研究计划将提供背景，使他能够 继续培训初学临床研究人员。候选人的 研究计划和对指导的承诺将得到以下补充 威斯康星大学特别研究和培训计划的优势 密歇根州(UM)。这些项目包括杰出的临床研究。 资金雄厚的综合临床研究中心的设施、资源 由几个主要研究中心(例如克劳德·佩珀)提供 中国科学院老年医学与老年医学研究所老年医学中心， 弗吉尼亚州安娜堡的教育和临床中心)，非常出色 通过密歇根大学课程整合的教育资源 老年研究计划和科学公共卫生学院 临床研究设计与统计分析课程。最后， 正在制定新的倡议，以促进创新的临床 UM的调查和临床研究人员的培训(例如 临床研究与临床培训中心 UM的调查人员(例如临床调查中心和 治疗学)。总而言之，候选人在耐心方面的成就- 以研究为导向，他指导临床的能力和承诺 调查员培训人员，以及密歇根大学的研究和培训优势 为实现……的具体目标提供理想的环境 这项提议。

The specific aims of this mid-career patient-oriented research award are: 1) to further establish the candidate's independent patient- oriented clinical research program in neurohumoral mechanisms of aging cardiovascular physiology, and 20 to provide the candidate the time and resources necessary to provide mentorship to trainees pursuing clinical investigation of aging cardiovascular physiology. The candidate has a record of continuously funded productive investigation in patient- oriented research dating from the beginning of this fellowship training in Geriatric Medicine in 1985 to the present. The candidate's patient- oriented research program is funded on the role of the sympathetic nervous system (SNS) and other neurohumoral systems in the regulation of blood pressure and cardiac contractility in normal human aging, and in older patients with hypertension and heart failure. The protected time afforded by this award will permit the candidate to further develop novel methods to assess the regulation of SNS activity, adrenergic receptor function and other neurohumoral mechanisms in older patients with hypertension and heart failure. The candidate has an established record of providing mentorship of pre- and post-doctoral trainees. The candidate's research program will provide the context to permit him to continue training beginning clinical investigators. The candidate's research program and commitment to mentoring will be complemented by the special research and training program strengths of the University of Michigan (UM). These programs include outstanding clinical research facilities in a well-funded General Clinical Research Center, resource provided by several major research centers (e.g. Claude Peppers Geriatrics Center, Institute of Gerontology and Geriatric Research, Education, and Clinical Center at the Ann Arbor VA), and excellent educational resources through the curricula of the UM integrated Geriatric Fellowship Program and the School of Public Health of Science Program in Clinical Research Design and Statistical Analysis. Finally, new initiatives are being developed to facilitate innovative clinical investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and Therapeutics). In summary, the candidate's accomplishment in patient- oriented research, his ability and commitment to mentor clinical investigator trainees, and the research and training strengths of the UM combine to provide an ideal context to accomplish the specific aims of this proposal.