NCI CFRBCCS INFORMATICS CENTER AT UCI

描述：先进的突变检测技术， 几个癌症易感基因，以及基因的高通量测序 使许多以前和现在的研究过时 癌症遗传流行病学的策略。 此外，临床 遗传突变的影响需要被定义和传达 健康护理提供者和癌症遗传学专业人员。 提供一种 人类癌症遗传学研究的基础设施规模空前 和复杂性，国家癌症研究所发起了合作， 乳腺癌和结肠癌研究家族登记处（CFRBCCS）。 的组成部分 这将是一个最先进的信息学中心， 开发、实施和维护中央信息系统，并提供 发展信息技术的技术专长， 统计方法和研究设计。 总的来说， 加州欧文分校（UCI）、达特茅斯医学院和 南加州在开发信息方面有着丰富的经验 管理系统，参与和协调多中心研究 努力，并开发生物统计学方面的先进技术。 此外，本发明还 生物统计学、遗传流行病学和 分子遗传学将作为生物统计学的成员参加， 遗传学和流行病学联合会提供技术专门知识， CFRBCCS研究人员。 我们的具体目标是：1）制定、实施和 在UCI维护一个单一的中央信息系统，2）提供摘要 为CFRBCCS登记册提供数据、支持和协调，3）提供 关于统计问题、研究设计、方法学 和信息技术， 生物统计学、遗传流行病学和 分子遗传学，4）履行CFRBCCS的职责 研究范围内的沟通、协调和管理职责。

DESCRIPTION: Advanced technology for mutation detection, the cloning of several cancer susceptibility genes, and high-throughput sequencing of genes make obsolete many of the previous and some of the current research strategies in the genetic epidemiology of cancer. In addition, the clinical implications of inherited mutations will need to be defined and communicated to health care providers and cancer genetics professionals. To provide an infrastructure for studies in human cancer genetics of unprecedented size and complexity, the National Cancer Institute has initiated the Cooperative Family Registry for Breast and Colon Cancer Studies (CFRBCCS). Integral to this effort will be a state-of-the-art Informatics Center (IC), that will develop, implement, and maintain a central informatics system and provide technical expertise for the development of information technologies, statistical methodology, and study design. Collectively, the University of California at Irvine (UCI), Dartmouth Medical School, and the University of Southern California have extensive experience in developing information management systems, participating in and coordinating multi-center research efforts, and developing advanced techniques in biostatistics. Further, leading international experts in biostatistics, genetic epidemiology, and molecular genetics will participate as members in the Biostatistics, Genetics, and Epidemiology Consortium, to provide technical expertise to CFRBCCS researchers. Our specific aims are: 1) Develop, implement, and maintain a single central informatics system at UCI, 2) Provide summary data, support, and coordination for the CFRBCCS registries, 3) Provide technical expertise regarding statistical issues, study design, methodology, and information technologies for the Registries, through an international consortium of leading experts in biostatistics, genetic epidemiology, and molecular genetics, 4) Carry out the responsibility for the CFRBCCS Study-wide communication, coordination, and administrative duties.