A randomised open-label study comparing the safety and efficacy of two alternative treatment options in the management of HIV-1 infected participants who have virologically failed a standard first-line combination ART regimen

在过去十年中，国际社会作出了前所未有的努力，将向所有艾滋病毒感染者提供获得护理的机会作为一项基本人权。这些人中的大多数都接受了一种简单的药物组合治疗，这些药物已被证明可以控制艾滋病毒。然而，当第一种药物组合不起作用时该怎么办尚不清楚。这项研究旨在填补这一知识空白，使患者第一次联合用药失败，可以提供第二次联合用药的最大成功机会。

For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.