Lifetime Risk of Cardiovascular Disease

描述（由申请人提供） 候选人已完成住院医师培训，首席住院医师和 在马萨诸塞州总医院（MGH）的心脏病学奖学金，以及 心脏病研究的研究员。在此期间，他开始 在哈佛医学院的临床研究方法的正式教学培训 公共卫生，他已经出版了几个主要的第一作者手稿 期刊他现在在麻省总医院心脏科工作， 哈佛医学院的任命。候选人寻求追求事业 作为一名临床科学家，作为一名顾问治疗心脏病患者 心脏病专家25%的时间承诺，重点是预防 心脏病学，同时投入75%的时间来发展所需的技能， 成为一名优秀的流行病学家和心血管疾病研究人员。 在这个更大的框架内，拟议的项目将进一步推动职业生涯 候选人的短期和长期目标。使用先前 从心脏研究中获得的新数据，候选人提出 研究动脉粥样硬化性心血管疾病的终生风险， 充血性心力衰竭更容易理解的终身风险数据 由一般公众比其他措施的风险，可能是有用的临床医生 加强公共卫生工作， 心血管疾病，这仍然是发病的主要原因， 死亡率在美国。还需要进一步研究 与不同风险因素分层相关的终生风险差异 (e.g.吸烟者与非吸烟者）。预计在2000年期间， 该奖项，候选人将获得解决这些问题所需的技能， 其他问题使用最适当的数据管理和统计 技术.通过在哈佛大学的教学课程的组合， 公共卫生，参与法国国家统计局正在进行的数据收集工作 研究，并在统计规划的指导下， 经验丰富的导师和合作者，候选人计划开发 完成拟议项目所需的技能，并为 作为一名心血管研究员的成功职业

DESCRIPTION (provided by applicant) The candidate has completed residency training, a Chief Residency and a fellowship in cardiology at Massachusetts General Hospital (MGH), as well as a research fellowship at the Framingham Heart Study. During that time, he began formal didactic training in clinical research methods at the Harvard School of Public Health, and he has published several first-author manuscripts in major journals. He is now on staff in the Cardiology Division at MGH with a faculty appointment at Harvard Medical School. The candidate seeks to pursue a career as a clinician-scientist, treating cardiology patients as a consultant cardiologist for 25% of his time commitment, with an emphasis on preventive cardiology, while devoting 75% of his time to developing the skills needed to become an excellent epidemiologist and researcher in cardiovascular diseases. Within this larger framework, the proposed project will further the career goals of the candidate in both the short- and long-term. Using previously acquired and new data from the Framingham Heart Study, the candidate proposes to examine the lifetime risks of atherosclerotic cardiovascular diseases and congestive heart failure. Lifetime risk data, which are more easily understood by the general public than other measures of risk, may be useful to clinicians and policy-makers in increasing public health efforts at prevention of cardiovascular diseases, which remain the major cause of morbidity and mortality in the United States. Further work is also needed to examine differences in lifetime risk associated with different risk factor strata (e.g. smokers versus non-smokers). It is anticipated that during the period of this award, the candidate will gain the skills required to address these and other questions using the most appropriate data management and statistical techniques. Through a combination of didactic courses at the Harvard School of Public Health, participation in ongoing data collection at the Framingham Study, and experience with statistical programming under the guidance of the experienced mentor and collaborators, the candidate plans to develop the skills necessary to complete the proposed project and to provide the basis for a successful career as a cardiovascular researcher.