WOMENS POOLING PROJECT

描述 （改编自申请人摘要）洛里莫斯卡博士是一名初级教师 密歇根大学心脏病学分部的成员， 最近完成了NRSA预防心脏病学培训计划， 获得了博士学位1996年5月在哥伦比亚大学的流行病学中。 在过去的两年里，她积极参与了 妇女联合项目，设立该项目是为了解决 需要有关妇女心血管危险因素和疾病的信息。 WPP的目标是联合收割机将过去40年来收集的数据从 长期的，以社区为基础的研究在美国，为目的， 检查妇女的健康问题，不能充分解决在一个 单一研究。 WPP是一项历史前瞻性研究， 具有近100%随访率、大量和种族特征的队列 多样性 将通过汇总以下数据来检查女性的心血管风险： 来自查尔斯顿心脏研究的12，000多名年龄在30 - 79岁之间的女性， 埃文县研究，心脏研究，兰乔贝尔纳多研究， 圣安东尼奥心脏研究和特库姆塞社区健康研究。 的 WPP包括风险因素，如年龄，血压，胆固醇， 糖尿病，体重指数，吸烟模式，教育水平， 电图检查结果。 进行了一项NHLBI赞助的试点研究， 证明了上述队列的合并数据是可行的。 初步 结果表明，有显着差异的负担， WPP中种族亚组的心血管危险因素。 的 传统心血管疾病（CVD）风险因素的患病率， 与各种原因、心血管疾病和冠心病引起的死亡率的关系 将根据总体和种族组确定冠心病（CHD）。 拟议 研究还将评价每个队列的相应男性数据， 将研究心血管危险因素负担的性别差异 全因死亡率，心血管疾病和冠心病。 这项研究将产生 关于女性心血管风险的及时数据，以及它与 可能有助于制定适当的预防战略， 不同的人群。 莫斯卡博士将根据 米利森特·希金斯博士的指导，一位国际公认的 心血管流行病学家。 该奖项的目标将是发展 博士让莫斯卡成为一名独立的研究员，这样她就能够 对心血管流行病学领域的贡献，特别是在 妇女健康领域。 (End摘要）

DESCRIPTION (Adapted from applicant's abstract) Dr. Lori Mosca is a Junior faculty member in the Division of Cardiology at the University of Michigan who recently completed an NRSA training program in Preventive Cardiology and received her Ph.D. in Epidemiology from Columbia University in May, 1996. Over the past two years she has been actively involved in the initiation of The Women's Pooling Project, which was established to address the critical need for information about cardiovascular risk factors and disease in women. The goal of the WPP is to combine data collected over the past 40 years from long term, community-based studies in the United States, for the purpose of examining health issues in women that cannot be adequately addressed in a single study. The WPP is a historical prospective study which has well characterized cohorts with nearly 100% follow-up, large numbers and ethnic diversity. Cardiovascular risk in women will be examined by pooling data on over 12,000 women aged 30 - 79 years from the Charleston Heart Study, the Evan's County Study, the Framingham Heart Study, the Rancho Bernardo Study, the San Antonio Heart Study, and the Tecumseh Community Health Study. The WPP includes risk factors such as age, blood pressure, cholesterol, diabetes, body mass index, smoking pattern, educational level, and electrographic findings. An NHLBI sponsored pilot study was conducted that demonstrated pooling data from the above cohorts was feasible. Preliminary results suggest there are striking differences in the burden of cardiovascular risk factors among ethnic subgroups in the WPP. The prevalence of traditional cardiovascular disease (CVD) risk factors and their relation to mortality due to all causes, CVD and coronary heart disease (CHD) will be determined overall and by ethnic group. The proposed study will also evaluate the corresponding male data from each cohort and will examine gender differences in the burden of cardiovascular risk factors on mortality due to all causes, CVD and CHD. This study will generate timely data regarding cardiovascular risk in women and how it differs from men that may be useful for developing appropriate preventive strategies for diverse populations. Dr. Mosca will conduct the proposed research under the guidance of Dr. Millicent Higgins, an internationally recognized Cardiovascular Epidemiologist. The goal of this award will be to develop Dr. Mosca into an independent researcher so that she will be able to make contributions to the field of Cardiovascular Epidemiology, specifically in the area of Women's Health. (End of Abstract)