ABERRATIONS OF EYES IN NORMAL AND CLINICAL POPULATIONS

描述（改编自申请人的摘要）：在美国， 白内障手术是30种手术中最常进行的手术。 医疗保险受益人，估计每年费用为35亿美元。 在巴尔的摩眼科调查中，据报道白内障是导致 40岁以上的人失明， 非裔美国人比白种美国人多。在世界范围内，白内障是 失明的主要原因。拟议的研究旨在采取一项 减少白内障导致失明的重要一步。评价 旨在延缓或预防白内障的预防性治疗的有效性 白内障早期发展和进展的新的敏感标志物 需要被识别。这一需要得到特别承认和反映， 透镜和白内障专家组报告的目标1：视觉研究，A 国家计划：1999-2003年。NEI报告的目标1是：“确定 有一些新的标记物可以区分正常的衰老过程和 病（白内障）状态。“为实现目标1，报告确定了 需要开发“可以 通过非侵入性技术可视化。“重新提交的具体目的是 是为了证明：波前传感可以量化光学像差 早期白内障形成的局部散射特性;波前传感 能区分正常衰老过程和白内障状态; 波前传感具有成为有效监测的准确性和精确性 用于延迟、预防或减缓新疗法的纵向研究工具 白内障的形成和发展。这些具体目标将通过以下方式实现： 修改哈特曼/夏克波前传感器技术，以量化光学 早期白内障眼的像差和局部散射特性， 正常人的眼睛在第四，第五和第六个十年的生活。

DESCRIPTION (Adapted From The Applicant's Abstract): In the United States, cataract surgery is the most frequently performed surgical procedure among 30 million Medicare beneficiaries at an estimated cost of $3.5 billion per year. In the Baltimore Eye Survey, cataract is reported as the leading cause of blindness in those over the age of 40, and to be four times more common in African-Americans than in Caucasian-Americans. In the world, cataract is the leading cause of blindness. The proposed research is designed to take a significant step toward reducing blindness resulting from cataract. To evaluate the effectiveness of preventative therapy designed to delay or prevent cataract formation, new sensitive markers of early cataract development and progression need to be identified. This need is specifically recognized and reflected in Objective 1 of the Report of the Lens and Cataract Panel in: Vision Research, A National Plan: 1999-2003. Objective 1 of the NEI report is to: "Determine if there are novel markers that differentiate the normal aging process from the diseased (cataractous) state." To meet objective 1, the Report identifies the need for the development of "morphological and optical markers that can be visualized by noninvasive techniques." The specific aims of the resubmission are to demonstrate that: wavefront sensing can quantify the optical aberrations and local scattering properties of early cataract formation; wavefront sensing can differentiate the normal aging process from the cataractous state; wavefront sensing has the accuracy and precision to be an effective monitoring tool in longitudinal studies of new therapy designed to delay, prevent, or slow cataract formation and progression. These specific aims will be accomplished by modifying Hartmann/Shack wavefront sensor technology to quantify the optical aberrations and local scattering properties of eyes with early cataract and eyes of normals in the 4th, 5th and 6th decades of life.