HIGH-RESOLUTION IMAGING OF OCULAR MELANOMA AND RETINA

描述(申请人的描述)：高分辨率成像可以改善 了解视网膜疾病和病理情况，特别是在 恶性脉络膜黑色素瘤、老年性黄斑变性、 糖尿病视网膜病变、艾滋病的眼部并发症和青光眼。眼睛可以 仅被视为光瞳直径以下的衍射受限光学系统 3毫米。标准的视网膜成像技术使用3毫米成像孔径来 避免外部角膜的高阶像差。然而，如果这些 高阶像差可以补偿，衍射限制成像在7 或者可以达到8 mm的光瞳直径。的数字光圈 瞳孔为7 mm或8 mm的衍射受限的眼睛可以观察到视网膜 这是眼科以前无法实现的细节。要做到这一点 目标我们计划开发一种波前传感器，它将允许我们测量 被测量的眼睛存在像差。我们将在眼睛模型中进行测试， 动物的眼睛和人类的眼睛。波前传感器将连接到一个 眼底相机和扫描激光检眼镜。第二个目标是使用 用于校正反馈环中像差的自适应波前补偿器 设置。我们将对整个波前传感器和波前系统进行测试 在眼睛模型、动物眼睛和人类眼睛中的补偿器。波前 补偿器将安装在眼底相机和扫描激光上 眼底镜。第三个目的是利用数字图像处理来校正 对于不能补偿的部分残余像差 由于机械方面的考虑，自适应波前补偿器。我们的团队 开发了一种波前传感器和波前补偿器。 微机械薄膜变形镜。由于数量有限， 电极，我们计算机系统的缓慢速度和机械硬度 我们不能完全矫正所有测量到的像差。 我们的初步工作表明，该系统能够允许波前 更正。在这项研究中，我们计划提高我们的 允许快速波前的波前传感器和波前补偿器 补偿。我们的初步结果表明，即使是最好的像差 补偿仍然受到残余波像差的影响。因为我们可以测量 并对这些像差进行了表征，可以开发出基于数字逆滤波的 根据我们在图像重建方面的经验，对采集到的图像进行校正。

DESCRIPTION (Applicant's Description): High-resolution imaging allows improved understanding of retinal disease and pathological conditions, particularly in prognosis of malignant choroidal melanoma, age-related macular degeneration, diabetic retinopathy, ocular complications of AIDS and glaucoma. The eye can only be regarded as a diffraction-limited optical system up to a pupil diameter of 3 mm. Standard retinal imaging technology uses a 3 mm imaging aperture to avoid the higher order aberrations of the outer cornea. However, if these higher order aberrations can be compensated, diffraction-limited imaging at 7 or 8 mm pupil diameter can be achieved. The numerical aperture of the diffraction-limited eye at 7 or 8 mm pupil will allow to visualize retinal detail that was previously not achievable in ophthalmology. To achieve this goal we plan to develop a wavefront sensor that will allow us to measure the existing aberrations of the measured eye. We will test it in an eye model, in animal eyes and in human eyes. The wavefront sensor will be attached to a fundus camera and scanning laser ophthalmoscopes. The second aim is to use an adaptive wavefront compensator to correct the aberrations in a feed-back loop setup. We will test the complete system of wavefront sensor and wavefront compensator in an eye model, in animal eyes and in human eyes. The wavefront compensator will be attached to a fundus camera and scanning laser ophthalmoscopes. The third aim is to used digital image processing to correct for the portion of the residual aberrations that could not be compensated with the adaptive wavefront compensator due to mechanical considerations. Our group has previous developed a wavefront sensor and wavefront compensator based on a micromachined membrane deformable mirror. Due to the limited number of electrodes, slow speed of our computer system and the mechanical stiffness of the membrane we were not able to completely correct all measured aberrations. Our preliminary work shows that the system is capable of allowing wavefront correction. In this study we plan to improve the acquisition speed of our wavefront sensor and wavefront compensator to allow rapid wavefront compensation. Our preliminary results have shown that even the best aberration compensation still suffers from residual wave aberrations. Since we can measure and characterize these aberrations, we can develop digital inverse filter based on our experience in image reconstruction to correct the acquired images.