SOLUABLE POLYMER SUPPORTS FOR ORGANIC SYNTHESIS

描述：聚合物支撑的化学经历了戏剧性的复兴。 主要的推动力是“小分子”的发展。 药物发现的组合技术但尽管 树脂如交联聚苯乙烯的普及和成功， 不溶性聚合物在有机溶剂中使用时具有许多缺点 合成.可能对反应速率有不利影响， 选择性和产率。并且光谱分析受到阻碍。 此外，固体载体在水中不是特别有效。 因此，许多目前有价值的生物催化转化不能 有效地执行。一个可溶性的支撑物可以让人们的期望 和传统溶液化学的方法，同时提供 聚合物相的优点。 调查人员已经开始了一项多方面的计划， 可溶性聚合物在有机合成中的应用。这包括 发现了用于合成应用的独特可溶性聚合物。 值得注意的是，一种被称为“平行聚合物合成”的方法将提供 获得大量的新材料。最后，示例如下 突出了可溶性技术在合成中的作用 前列腺素类和手性结构单元等复杂分子。这 将包括图书馆建设和实施聚合物- 支持的技术称为“振荡液相”成为可能， 我们的新型共聚物的物理性能差异。是 预计可溶性聚合物载体将发现越来越多的用途 在未来几年的综合。

DESCRIPTION: Polymer-supported chemistry has undergone a dramatic revival. The primary impetus has been the development of "small-molecule" combinatorial technology for drug discover. However, despite the popularity and successes of resins such as cross-linked polystyrene, insoluble polymers have a number of drawbacks for use in organic synthesis. There can be detrimental effects on reaction rates, selectivities and yields. and spectroscopic analyses are hampered. Furthermore, solid supports are not particularly effective in water. Hence, a number of currently valuable biocatalytic transformations can not be efficiently performed. A soluble support would allow the expectations and methods of traditional solution chemistry, while affording the benefits of the polymer phase. The investigators have embarked on a multifaceted program to develop the utility of soluble polymers in organic synthesis. This includes the discovery of unique soluble polymers for synthetic applications. Significantly a method coined "parallel polymer synthesis" will provide access to a large number of novel materials. Finally, examples are presented that highlight the power of soluble technology in the synthesis of complex molecules such as prostanoids and chiral building blocks. This will include library construction and the implementation of a polymer- supported technique termed the "oscillating liquid phase" made possible by the variance in physical properties of our new co-polymers. It is anticipated that soluble-polymer supports will finding increasing utility in synthesis in the coming years.