NORTH CENTRAL CANCER TREATMENT GROUP

北方中心癌症治疗小组（NCCTG）是一个多学科研究组织，主要由社区医生组成，与马约诊所癌症中心（NCI指定的综合癌症中心）合作，后者作为其主要研究基地。其广泛的长期目标是：1）开发和测试癌症治疗的新方法，以提高恶性疾病成人患者的生存率和生活质量，2）为癌症患者提供在其家庭社区进行最先进临床试验的机会，3）通过转化研究和临床数据库分析促进阐明癌症生物学的发现，这将导致治疗的改进，4）为癌症预防和症状管理研究提供平台和基础设施，5）为服务不足的人群提供NCCTG临床研究方案。NCCTG战略的前提是，社区诊所可以进行高质量的癌症治疗研究，社区诊所为新的癌症治疗程序对普通人群的适用性提供了最终的证明。具体目标是推进胃肠癌、乳腺癌、肺癌、脑肿瘤、血液恶性肿瘤和选择其他成人实体瘤患者的治疗;确定将导致更好的癌症治疗的肿瘤治疗。NCCTG用于实现其目标的方法包括试点、II期和III期临床试验;对参与临床试验的患者的组织标本或血液样本进行的实验室相关研究;以及临床和实验室数据库分析。

The North Center Cancer Treatment Group (NCCTG) is a multi- disciplinary research organization comprised primarily of community physicians in concert with the Mayo Clinic Cancer Center (an NCI- designated Comprehensive Cancer Center) which serves as its primary Research Base. Its broad, long-term objectives are to 1) develop and test new methods of cancer treatment to improve survival and quality of life for adult patients with malignant disease, 2) provide cancer patients access to state-of-the-art clinical trials in their home community, 3) promote discoveries elucidating the biology of cancer through translational research studies And analyses of clinical databases which will lead to improvements in therapy, 4) provide a platform and infrastructure for studies of cancer prevention and symptom management, and 5) provide underserved populations access to NCCTG clinical research protocols. The NCCTG strategy is based on the premises that quality cancer treatment research can be conducted by the community clinic, and that the community clinic provides the ultimate proving ground for applicability of new cancer treatment procedures to the general population. Specific aims are to advance the treatment of patients with gastrointestinal cancer, breast cancer, lung cancer, brain tumors, hematologic malignancies, and select other adult solid tumors; to identify tumor treatment which will lead to better cancer therapy. Methods utilized by the NCCTG to achieve its goals include pilot, phase II, and phase III clinical trials; laboratory correlative studies performed on tissue specimens or blood samples from patients participating in clinical trials,; and analyses of clinical and laboratory databases.