Early Goal-Directed Sedation compared with standard care in mechanically ventilated critically ill patients: a prospective multicentre randomised controlled trial.

几乎每一个重症监护病人都需要镇静药物来安慰和提供挽救生命的治疗。然而，镇静剂会引起副作用，包括昏迷、谵妄和躁动。目前还没有高水平的证据来帮助医生决定选择哪种镇静剂以及最好的给药方式。SPICE试验将测试一种名为早期目标导向镇静的新方法，该方法基于一种替代镇静剂，以观察它是否能提供更安全、有针对性的轻度镇静，同时减少谵妄。

Almost every patient in intensive care needs sedating drugs for comfort and provision of life-saving treatment. However, sedation causes side effects including coma, delirium and agitation. There is no high-level evidence to help doctors decide which sedatives to choose and the best way to administer them. The SPICE trial will test a new approach called Early Goal-Directed Sedation based on an alternative sedative agent to see whether it delivers safer, targeted light sedation with less delirium.