NEURONAL CORRELATES OF HUMAN MEMORY

描述：（研究者摘要）：人类记忆的神经机制 利用一个独特的机会进行调查，开颅手术， 在手术的一部分中，患者在局部麻醉下是清醒的。 在这些操作的部分，神经活动发生与记忆 测量是由细胞外微电极记录在人体侧 颞叶和内嗅皮层以及海马体。 多方面或记忆 在这些记录中进行评估，包括长期语义，最近 外显后分心，工作，内隐记忆和回忆， 检索的识别模式。 记忆的这些不同方面是 评估了三种类型的口头材料，视觉呈现的名称， 物体、词语和听觉词语。 根据我们先前的观察，我们 希望能识别出与记忆的各个方面相关的神经元， 外侧颞叶皮层以及内侧颞叶结构。 单个神经元将与记忆的特定方面相关， 记忆的同一个方面，到一个特定类型的口头材料。 每个 每种语言材料的记忆方面都有不同的神经系统， 颞叶系统 因此，本研究将更清楚地定义 人类语言记忆的细分，并建立一些变化， 神经活动与它们一起发生。

DESCRIPTION: (Investigator's Abstract): Neural mechanisms of human memory are investigated utilizing a unique opportunity, craniotomy where the patient is awake under local anesthesia for a portion of the operation. During the portion of these operation, neural activity occurring with memory measures is recorded by extracellular microelectrodes in human lateral temporal and entorhinal cortex, and hippocampus. Multiple aspects or memory are evaluated during those recordings, including long-term semantic, recent explicit post-distractional, working, and implicit memory and recall and recognition modes of retrieval. These various aspects of memory are assessed for three types of verbal material, visually presented names of objects and words and auditory words. based on our previous observation, we expect to identify neurons related to the various aspects of memory in lateral temporal cortex, as well as more medial temporal structures. Individual neurons will be related to a specific aspect of memory, and for the same aspect of memory, to a specific type of verbal material. Each aspect of memory for each type of verbal material has separate neural systems in temporal lobe. This study, then, will more clearly define the subdivisions of human verbal memory and establish some of the changes in neural activity occurring with them.