Effect of O2 Stress and Aging on Single Myocyte Function

描述：(申请人提供)骨骼肌功能随着 年龄。随着男性平均预期寿命的增加和S的不断增加 世界各地的老年人口，科学研究正试图保护 老龄化人口？S的生活质量。处于解释前沿的一种理论 对于衰老的影响一直是免费的累积负面影响 随着时间的推移，激进的生产。有证据表明，衰老的生物体 越来越容易受到活性氧物种(ROS)的损害。在……里面 除了在衰老过程中观察到的进行性萎缩和功能衰退之外 骨骼肌，老年人常见的呼吸系统疾病 而血液循环不足会不会危及身体？S的输送能力 氧气进入全身的组织。这些老化的综合影响和 骨骼肌缺氧严重损害了这些人的功能能力 并进一步加速丧失身体上的独立性。我提议 使用单个骨骼肌纤维模型，其中实验条件可以 受到严格控制，几种细胞内因子可以在 完好无损，纤维收缩。通过研究老年人身上发生的变化 肌肉？S氧化应激及其对运动和低氧的反应能力，a 更好地理解运动处方和药物疗法如何预防 或随着年龄的增长而改善肌肉功能。

DESCRIPTION: (provided by applicant) Skeletal muscle function declines with age. With the increase in man?s average expected life span and the increasing elderly population worldwide, scientific research is attempting to preserve the aging population?s quality of life. One theory at the forefront of explanations for the effects of aging has been the cumulative negative effects of free radical production over time. Evidence suggests that aged organisms grow increasingly vulnerable to damage from reactive oxygen species (ROS). In addition to the progressive atrophy and functional declines observed in aging skeletal muscle, common medical conditions in the elderly such as respiratory and circulatory insufficiencies can compromise the body?s ability to deliver oxygen to tissues throughout the body. These combined effects of aging and hypoxia on skeletal muscle car severely compromise functional capacity in these individuals and further hasten the loss of physical independence. I propose to use the single skeletal muscle fiber model in which experimental conditions can be tightly controlled and several intracellular factors can be examined in an intact, contracting fiber. By I studying the alterations that occur in the aged muscle?s oxidative stress and its ability to respond to exercise and hypoxia, a better understanding of how exercise prescription and drug therapy can prevent or improve muscle function with age may be achieved.