CORE--NEUROPATHOLOGY

UCLA-阿尔茨海默病研究的神经病理学（NP）核心 中心（以下简称ADRC）将进行完整或“仅限大脑”尸检 对参加尸检计划的病人，以及 神经退行性疾病（和适当的控制），并将sere 作为个体执行以下操作的数据和组织/流体资源： Alzheimer病/Alzheimer老年性痴呆创新研究 型（AD/SDAT），非AD痴呆，以及其他感兴趣的科学家 神经退行性疾病适当尸检的脑组织 将在尸检时进行分类和储存，以优化 它们随后用于结构和分子/药理学研究。 组织采集方法将是在第一次 加州大学洛杉矶分校阿尔茨海默病中心（ADC）的八年资助， 即材料将冷冻储存，多聚甲醛固定（与 随后包埋在LR白色塑料中）或石蜡块中。组织 NP Core的研究将包括系统性阻断固定的大脑 组织、常规和专门的银菌株， 显微镜下AD相关病变（老年斑和神经胶质瘤） 缠结），以及使用市售的 NP中开发的可用抗体和抗体/试剂/探针 核心研究者或合作研究者。因此，提供的组织/液体 将被仔细和系统地评估 AD和相关疾病的治疗尸检患者信息 也将提交给ADRC数据库，并在其中维护， 确保其可供研究者进行临床研究， 或基础研究。NP Core的其他一般功能包括 (a)与临床核心和成像子核心互动，以提供 用于ApoE基因分型和其他工作的组织，（c） 形态学/免疫组织化学支持正在进行的AD相关（和 基于动物模型的）研究和项目负责人直接合作 （d）与社区病理学家联络 他们被要求评估尸检脑组织， （d）与非专业团体讨论尸体解剖的重要性 （e）与教育中心合作， 进行，优化和评估每月痴呆症的教学价值- 相关临床病理会议。

The Neuropathology (NP) Core of the UCLA-Alzheimer's Disease Research Center (hereafter ADRC) will perform complete or "brain only" autopsies on patients enlisted in the Autopsy Program, as well as patients with over neurodegenerative diseases (and appropriate controls) and will sere as a data and tissue/fluid resource for individuals performing innovative research on Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), non-AD dementias, and other scientists interested in neurodegenerative conditions. Brain tissues from appropriate autopsies will be triaged and stored at the time of necropsy in order to optimize their subsequent use of structural and molecular/pharmacologic research. The tissue harvesting method will be one developed during the first eight years of funding of the UCLA Alzheimer's Disease Center (ADC), i.e. materials will be stored frozen, paraformaldehyde fixed (with subsequent embedding in LR White plastic), or in paraffin blocks. Tissue studies in the NP Core will include systematic blocking of fixed brain tissue, routine and specialized silver strains that demonstrate microscopic AD-related lesions (senile plaques and neurofibrillary tangles), and immunohistochemical staining using both commercially available antibodies and antibodies/reagents/probes developed in the NP Core or with collaborating investigators. Thus tissues/fluids provided to investigators will have been carefully and systematically assessed for AD and related disease processes. Information on autopsied patients also will be submitted to, and maintained in, the ADRC Database, ensuring its availability to investigators carrying out either clinical or basic studies. Other general functions of the NP Core will include (a) Interactions with the Clinical Core and Imaging Sub-core to provide tissues for ApoE genotyping and other work, (c) Morphologic/immunohistochemical support of ongoing AD-related (and animal model-based) studies and Project Leaders by direct collaboration or provision of key reagents, (d) Liaison with community pathologists who are called upon to asses autopsy brain tissue from demented patients, (d) Discussion with lay groups of the importance of autopsies on demented patients, and (e) Collaborating with the Education Core to conduct, optimize and assess the didactic value of a monthly dementia- related clinicopathologic conference.