课题基金 / 基金详情

PROSPECTIVE STUDY TO DETERMINE THE EFFICACY AND SAFETY OF AZATHIOPRINE

PROSPECTIVE STUDY TO DETERMINE THE EFFICACY AND SAFETY OF AZATHIOPRINE
确定硫唑嘌呤功效和安全性的前瞻性研究
批准号：
6304925
负责人：
Robert E Shaddy
金额：
$0.16万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6304925
关键词：
azathioprine child (0-11) clinical research clinical trial phase I drug adverse effect drug screening /evaluation heart surgery homologous transplantation human subject human therapy evaluation immunotherapy pediatric pharmacology

项目摘要

项目成果

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中文摘要
翻译
在这项研究中，研究了一种抑制免疫系统的药物对在先天性心脏缺陷修复手术中接受人体解剖瓣膜的儿童的影响。为了做到这一点，一半的孩子接受了这种药物治疗，另一半没有。所有患儿术后1周、1个月和3个月抽血，测量患儿对人体解剖瓣膜的免疫反应。进行心脏超声检查，观察两组患者在瓣膜功能方面是否有差异。两组之间在免疫反应或瓣膜功能方面没有发现差异。
英文摘要
In this study, the effect of a drug that suppresses the immune system was studied on children who received a human autopsy valve at the time of surgery for repair of a congenital heart defect. To do this, one-half of the children received this medication and the other one-half did not. Blood samples were drawn on all children 1 week, 1 month, and 3 months after surgery and the immune response of the children to the human autopsy valve was measured. Heart ultrasound tests were obtained to see whether there was any difference between the 2 groups with regard to valve function. No difference was found between groups with regard to the immune response or valve function.
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GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE
  • 批准号：
    7718531
  • 项目类别：
  • 资助金额：
    $0.06万
  • 财政年份：
    2008
  • 负责人：
    Robert E Shaddy
  • 依托单位：
    UNIVERSITY OF UTAH
GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE
  • 批准号：
    7604988
  • 项目类别：
  • 资助金额：
    $0.39万
  • 财政年份：
    2007
  • 负责人：
    Robert E Shaddy
  • 依托单位：
    UNIVERSITY OF UTAH
GENETIC POLYMORPHISMS IN CHILDREN WITH CONGENITAL HEART DISEASE
  • 批准号：
    7376472
  • 项目类别：
  • 资助金额：
    $0.63万
  • 财政年份：
    2006
  • 负责人：
    Robert E Shaddy
  • 依托单位：
    UNIVERSITY OF UTAH
CARVEDILOL IN CHILDREN WITH CONGESTIVE HEART FAILURE
  • 批准号：
    7201453
  • 项目类别：
  • 资助金额：
    $3.35万
  • 财政年份：
    2005
  • 负责人：
    Robert E Shaddy
  • 依托单位：
    UNIVERSITY OF UTAH