Core--Animal Handling

该核心的主要目标有三个方面。1)根据本计划项目资助的所有研究者的需要，生产发育阶段的动物（例如妊娠、哺乳或退化），2）提供乳腺特异性和一般外科支持，3）协助乳腺组织的形态学和组织学评价。下文详细介绍了该核心实现这些目标的能力。动物核心还将作为该项目研究人员之间组织共享的协调中心。Dr. Neville的经验是，必须从实验室直接指派人员与动物处理中心和动物资源中心合作，生产和管理定时妊娠和哺乳小鼠。本程序项目的所有研究者都需要此功能。此外，动物实验涉及一些熟练的技术，所有研究者都需要有一名经过充分培训的人员。由特定项目产生的组织可以在其他项目中找到用途。协调的组织共享将促进这些项目之间的互动。

The primary objectives of this core are three fold. 1) to produce developmentally staged animals (e.g. pregnant, lactating or involuting) as needed by all investigators in this program project grant, 2) to provide mammary-specific and general surgical support, and 3) to assist in the morphological and histological evaluation of mammary tissues. The capability of the core to meet these objectives is detailed below. The animal core will also serve as a center for coordination of tissue sharing among investigators in the program project. It is the experience of Dr. Neville that personnel must be directly assigned from their laboratories to work with the Animal Handling Core and the Animal Resource Center in the production and management to timed pregnant and lactating mice. This function is required by all investigators on this program project. In addition there are some skilled techniques involved in the animal experiments for which a fully trained individual needs to be available for all investigators. Tissues generated by a given project may find use in other projects. Coordinated tissue sharing will facilitate these interactions across projects.