A platform for the generation of natural product-based non-ribosomal peptide libraries

描述：非核糖体肽是一类有趣的天然产物，其中一些成员对多种疾病表现出令人印象深刻的生物活性。因此，它们已被广泛用作治疗剂。基于这些结构的化合物文库的生成和筛选平台将在药物发现中具有极大的价值。在这里，我们将开发一种生成天然产物类化合物随机文库的方法。这些化合物将用于测定对特定蛋白质相互作用的抑制作用。

A platform for the generation of natural product-based non-ribosomal peptide librariesdescription: Non-ribosomal peptides are an interesting class of natural products, with several members showing impressive bioactivity against a variety of diseases. As such they have been extensively employed as therapeutic agents. A platform for the generation and screening of compound libraries based on these structures would be extremely valuable in drug discovery. Here, we will develop a method for the generation of randomised libraries of natural-product-like compounds. These compounds will be assayed for inhibition of a given protein-protein interaction.