MRS OF MASSETER MUSCLE IN LONG FACE SYNDROME

我们继续致力于改进研究方法。 使用质子磁学检测乳房疾病，特别是癌症 共振光谱学。我们的假设仍然是乳腺癌 总胆碱浓度水平高于良性患者 乳房病变。我们的研究是在1.5T临床磁共振上进行的 使用定制的四通道多线圈组件的扫描仪 矢状按压乳房。我们利用了对比度增强的 磁共振成像和单体素质子磁共振成像在回声时间为31和 270毫秒。在过去的一年里，我们研究了乳房病变 26名妇女，并通过针吸活检进行病理对照 或手术后标本。这一人口中有17名女性 乳腺恶性病变9例，良性病变9例。这位夫人 检查是通过抽样标称体素大小小于 4cc，由MR图像规定。光谱显示 水和流动脂肪酸的共振；在大多数情况下 癌症，含胆碱化合物的N-三甲基共振 当时也是在3.2ppm。用Cho的存在作为一种测试 对于恶性肿瘤，我们整个患者的敏感性和特异性 人口(N=55)分别为79%和95%。这个 本试验阳性预测值为96%，阴性预测值为75%。 空间局域质子磁共振波谱可以提供足够的灵敏度和 1.5T光谱分辨率观察人体乳房胆碱 损伤。检测胆碱的存在是对 可用于描述乳房病变的恶性肿瘤 其自身或结合MRI标准。

We have continued our research efforts at improving methods of detecting breast disease, especially cancer, using proton Magnetic Resonance Spectroscopy. Our hypothesis remains that breast carcinomas have higher levels of total choline concentration than those of benign breast lesions. Our studies were performed on a 1.5T clinical MR scanner using a custom-built four channel multicoil assembly which compresses the breast sagittally. We made use of contrast-enhanced MRI and single voxel proton MRS using STEAM at echo times of 31 and 270 msec. Over the past year, we have studied breast lesions in twenty-six women, and made pathologic correlations using needle biopsy or post-surgical specimens. This population had 17 women with malignant breast lesions and 9 women with benign processes. The MRS examination was performed by sampling nominal voxel sizes less than 4cc which were prescribed from the MR images. Spectra showed resonances from water and mobile fatty acids; in a majority of carcinomas, the N-trimethyl resonance of compounds containing choline at 3.2 ppm was present as well. Using the presence of Cho as a test for malignancy, the sensitivity and specificity of our entire patient population (N=55) were calculated at 79% and 95%, respectively. The positive and negative predictive values of this test were 96% and 75%. Spatially localized proton MRS can provide sufficient sensitivity and spectral resolution at 1.5 T to observe choline in human breast lesions. Testing for the presence of choline serves as a test for malignancy that is useful in characterizing breast lesion either on its own or in combination with MRI criteria.