VITAMIN E IN TREATMENT OF IGA NEPHROPATHY IN CHILDREN

伊加肾病是一种肾脏疾病，它导致尿液中的血液和蛋白质流失，甚至在儿童时期开始时也会导致严重的肾衰竭。 不幸的是，伊加肾病没有经过证实的治疗方法，尽管已经尝试了许多药物。维生素E是一种天然存在的物质，具有“抗氧化”作用，这意味着它可以防止某些含氧物质（称为“自由基”）造成的损害。根据对实验性伊加肾病大鼠的研究，一些研究人员认为，给伊加肾病儿童服用维生素E可能会减少或防止肾瘢痕形成，从而减少肾衰竭的机会。这是一项多中心研究，其中患有活检证实的临床轻度伊加肾病的儿童和年轻人将随机接受维生素E或安慰剂，每日一次，持续两年。将对研究中的受试者进行肾功能、血尿（尿中带血）和蛋白尿变化的随访，以了解维生素E是否是伊加肾病的有效治疗方法。

IgA nephropathy is a disease of the kidneys which leads to loss of blood and protein in the urine and can lead to severe kidney failure even when it begins in childhood. Unfortunately, there is no proven treatment for IgA nephropathy, although numerous medications have been tried. Vitamin E is a naturally occurring substance that has "anti-oxidant" effects, meaning that it can protect against damage caused by certain oxygen-containing substances called "free radicals. Based upon studies in rats with experimental IgA Nephropathy, some researchers feel that giving Vitamin E to children with IgA Nephropathy may reduce or prevent the development of kidney scarring and therefore reduce the chances of developing kidney failure. This is a multicenter study in which children and young adults with biopsy-proven, clinically mild IgA Nephropathy will be randomized to receive either Vitamin E or placebo once daily for two years. Subjects in the study will be followed for changes in kidney function, hematuria (blood in the urine), and proteinuria to learn whether Vitamin E is an effective treatment for IgA Nephropathy.