500 MHz Wide Bore NMR System

描述(由申请人提供)：此申请申请500美元的资金 兆赫大口径自屏蔽核磁共振系统 纪念斯隆凯特琳癌症中心(MSKCC)。MSKCC目前有一个核磁共振 适用于细胞和活体研究的仪器，4.7T Omega系统(33厘米 钻孔磁铁)，于1988年购买。这块磁铁的操纵台正在升级 但它的场强已经不再是最先进的了 得到了一个外部审查小组和几个拨款批评的认可。在最后一次 1.5年来，MSKCC的成像相关资金大幅增加 包括小动物成像基金、细胞和分子成像基金 中心和生物工程联盟赠款，以及多个 第一批拨款。根据最近调查人员和资助项目的增加， 还需要更多的核磁共振研究设备。我们选择了这个 仪器，因为它提供最高的磁场在严重的 空间和资金的限制，它补充了4.7T系统，并在 与升级后的4.7T系统相结合，将服务于几乎所有 MSKCC对成像和代谢研究感兴趣的研究人员的需求。 该计划将支持来自16名研究人员的22项拨款。那里 是六个主要用户和第七个主要“群体”(鼠标成像以确定 肿瘤形成的基因外显率--5名参与者)。主要用户群 包括药理学、细胞生物学、医学物理学、神经学和 放射学。支持的22项赠款还包括外科手术的申请， 医学和放射肿瘤学。这些科学家中的大多数人都表现出了 对于核磁共振的支持，从大多数项目都有初步数据这一事实可以看出。 其中两名调查人员来自纽约医院，邻近的一家(独立)医院 机构。这项提议的一个优点是，如果它得到资助，它支持 在一个包含五个主要领域的细胞和体内成像研究中 除了一个主要的动物医疗中心外，还有医疗/研究机构。 这些机构中有三个共享共同的动物服务，因此 来自多个机构的动物可以被研究，而不是害怕 交叉感染。因此，这个应用程序将对外部有一些好处 除了MSKCC广泛的研究人员基础之外，还有许多机构。值得注意的是 在过去，我们与4家外部机构中的3家进行了合作，例如 被两个外部项目注意到(有支持性的初步数据)，并打算 继续这样做。因此，这项建议，如果得到资助，将支持非常广泛的 这一地区的科学家和医学研究人员的基地。

DESCRIPTION (provided by applicant): This application requests funds for a 500 MHz wide bore, self shielded, nuclear magnetic resonance (NMR) system for Memorial Sloan Kettering Cancer Center (MSKCC). MSKCC currently has one NMR instrument suitable for cellular and in vivo studies, a 4.7T Omega system (33cm bore magnet), purchased in 1988. The console of this magnet is being upgraded but its field strength is no longer ?state of the art" and this has been recognized by an outside review panel and several grant critiques. In the last 1.5 years there has been a major increase in imaging related funding at MSKCC including a Small Animal Imaging Grant, A Cellular and Molecular Imaging Center, and a Biological Engineering Consortium Grant, in addition to multiple R0l grants. Based on recent increases in investigators and funded projects, there is also a need for more NMR research equipment. We have selected this instrument since it provides the highest magnetic field available within severe constraints of space and money, it complements the 4.7T system, and in combination with the upgraded 4.7T system, will serve virtually all of the needs of investigators at MSKCC interested in imaging and metabolic research. There are 22 grants from 16 investigators that this program will support. There are six major users and a seventh major "group" (mouse imaging to determine gene penetrance for tumor formation - 5 participants). The major user group encompasses Pharmacology, Cell Biology, Medical Physics, Neurology, and Radiology. The 22 supported grants also include applications from Surgery, Medicine, and Radiation Oncology. Most of these scientists have shown a need for NMR support as shown by the fact that most projects have preliminary data. Two of the investigators are from New York Hospital, an adjacent (independent) institution. A strength of this proposal if it is funded, is that it supports cellular and in vivo imaging research in an area that encompasses five major medical/research institutions, in addition to a major animal medical center. Three of these institutions share a common animal service, and therefore animals from multiple institutions can be studied without fear of cross-infection. Thus this application will have some benefit to outside institutions, in addition to a broad base of researchers at MSKCC. It is noted that in the past we have collaborated with 3 of the 4 outside institutions, as noted by two outside projects (with supportive preliminary data), and intend to continue to do this. Thus this proposal, if funded , will support a very broad base of scientist and medical researchers in this area.