TRAINING IN MOLECULAR AND CELL BIOLOGY OF ALLERGY

这一三机构培训方案于1992年底组织，NIAID于1994年7月开始提供资金。它利用了La Jolla科学界广泛开展的联合过敏研究活动。教职员工来自邻近的三个研究所-拉霍亚过敏和免疫学研究所(LIAI)、斯克里普斯研究所(TSRI)和加州大学圣地亚哥分校(UCSD)。这三个中心的研究重点不同，但目标相同。总而言之，这些研究领域几乎涵盖了过敏研究中的所有主要问题。因此，学员将有机会接触到广泛的研究课题。此外，机构间培训方案是促进来自不同机构的研究人员之间的互动和合作的催化剂。所有教员都有完善的研究计划；他们的研究背景多种多样，综合起来包括免疫学、生物化学、细胞生物学和分子生物学。因此，该培训计划代表了一种跨学科的方法。受训人员可参与以下研究领域：1)IgE产生的调节，包括Th1/Th2分化；2)炎症细胞的生物学，包括肥大细胞和嗜酸性粒细胞；3)T细胞的生物学；4)关键参与过敏反应的细胞受体；5)信号转导；6)炎症介质/细胞因子；7)上皮细胞的功能；7)细胞黏附。该计划的目标是1)为学员提供对过敏性疾病发病机制的基本了解；2)促进学员调查技能的发展，特别是应用分子和细胞生物学方法来研究疾病的机制。该计划向对疾病相关问题感兴趣的博士和医学博士开放，并致力于临床科学基础研究的事业。预计学员将全身心投入研究，培训将以会议、研讨会、期刊俱乐部和课程为补充。可以预期，学员将在过敏性疾病的发病机制和过敏性炎症的分子和细胞机制方面发展坚实的背景，并成为合格和有信心开始他们的职业生涯的独立研究人员在过敏性研究。受训者获得的广泛专业知识和经验将使他们为生物医学的总体独立研究做好准备。

This tri-institutional training program was organized in late 1992 and the funding by NIAID began in July 1994. It takes advantage of the combined extensive allergy research activities in the La Jolla scientific community. The faculty members are from three neighboring institutes- La Jolla Institute for Allergy and Immunology (LIAI), The Scripps Research Institute (TSRI), and University of California, San Diego (UCSD). The three centers have different research emphases, while sharing a common goal. Together, the research areas encompass nearly all the major issues in allergy research. Therefore, the trainees will have opportunities to be exposed to a wide range of research topics. In addition, the inter-institutional training program serves as a catalyst for promoting interactions and collaborations among researchers from different institutes. All faculty members have well-established research program; their research backgrounds are diverse and when taken together encompass immunology, biochemistry, cell biology, and molecular biology. Therefore, this training program represents an interdisciplinary approach. The trainees can be involved in the following research areas: 1) regulation of IgE production, including Th1/Th2 differentiation; 2) biology of inflammatory cells, including mast cells and eosinophils; 3) biology of T cells; 4) cell receptors critically involved in allergic reactions; 5) signal transduction; 6) Inflammatory mediators/cytokines; 7) functions of epithelial cells; and 7) cell adhesion. The goals of the program are 1) to provide trainees with a basic understanding of pathogenesis of allergic diseases; and 2) to foster the development of trainee's investigative skills, in particular, applying molecular and cellular biological approaches to study mechanisms of diseases. The program is open to Ph.D.s and M.D.s interesting in disease-oriented problems and committed to career in basic research in clinical sciences. The trainees are expected to devote full time to research, and training will be supplemented by conferences, seminars, journal clubs and courses. It can be expected that trainees will develop a solid background in pathogenesis of allergic diseases and molecular and cellular mechanisms of allergic inflammation and become qualified and confident in embarking upon their careers as independent investigators in allergy research. The broad expertise and experience the trainees acquire will prepare them for independent research in biomedicine in general.