BIOPHYS STUD OF PROTEINS, NUCLEIC ACIDS, AND VIRUSES

普渡大学的生物物理培训补助金继续大力强调结构生物学，同时增加了来自涉及和影响结构生物学的其他学科的教师导师的代表。在此期间，指导人员从19人增加到22人，来自六个不同系的所有成员全部或部分参与了结构生物学的某些方面。代表了两个新的系，并增加了来自生物、生物化学和物理的导师数量。X射线衍射仪、核磁共振谱仪、电子显微镜等基础核心研究设备有了很大的扩展和提高。六个重叠的研究领域(可溶性蛋白质、膜蛋白和毒素的结构-功能、核酸结构-功能和蛋白质-核酸相互作用、病毒结构-功能、计算方法和金属蛋白)可以被确定为至少四名教员的教员群规模。这些互动导致了53份出版物，涉及至少两名教员，在两个授权期内，13名生物物理学实习生也参加了这两个时期。在此期间，过去和现在的生物物理学发表了132篇论文和演讲摘要以及专业会议。过去的学员中，有很大一部分人目前在大学或工业领域积极从事研究工作。在上一次赠款期间，来自代表性不足的少数群体和妇女的受训人员中有重要和重要的代表。学生和教职员工都参加了一个关于伦理和科学重要问题的讨论小组，受到了热烈的欢迎。研究生课程设置有所改进，并保持了对数量的高度重视。该方案的新的教育方面是每年举办一次面向学生的生物物理学研讨会，已经举办了三次，并在研讨会前由不同的导师就中心概念进行“生物物理讨论”，将在即将举行的研讨会上介绍。每周一次的结构生物学研讨会和每两周一次的结构生物学期刊俱乐部仍然是定期的研究和培训活动。

The biophysical training grant at Purdue University has continued its strong emphasis on structural biology, while increasing the representation of faculty mentors from other disciplines which involve and affect structural biology. The mentoring faculty has increased from 19 to 22 in this period, with all members from six different departments either fully or partly involved in some aspect of structural biology. Two new departments are represented, and the number of mentors from biology, biochemistry, and physics as increased. The basic core research equipment, X-ray diffractometers, NMR spectrometers, and electron microscopes, has expanded and improved greatly. Six areas of overlapping research interests (structure-function of soluble proteins, membrane proteins and toxins, nucleic acid structure-function and protein-nucleic acid interactions, virus structure-function, computational approaches and metalloproteins) can be identified with a minimum faculty cluster size of at least four faculty members. These interactions had led to fifty-three publications involving at least two faculty members over the two grant periods in which thirteen biophysics trainees have also participated. During this time, past and current biophysics have contributed to 132 publications and abstracts of presentations and professional meetings. A high fraction of past trainees are currently working actively in research at universities or in industry. During the last grant period, there has been important and significant representation among the trainees from under-represented minorities and women. A discussion group on important issues of ethics and science, involving both students and faculty, has been enthusiastically received. The graduate course curriculum has improved and maintained a high degree of emphasis on quantitation. New educational aspects of the program have been an annual-student oriented biophysics symposium, already presented three times, and pre-seminar "biophysical discussions" given by different mentors on central concepts to be presented in upcoming seminars. The weekly structural biology seminars and bi-weekly structural biology journal club have continued to be regular research and training events.