CORE--CELL BIOLOGY

该计划项目代表了一个有凝聚力的实验室团体， 有着共同目标和战略的研究人员， 将基因转移到祖细胞和分化细胞中。这些 实验室也需要几种技术，如 基因转移载体的创建和生成数据的分析 通过基因转移研究。细胞生物学核心设施旨在 为这组研究人员提供各种成像， 显示载体与靶细胞相互作用的检测方法， 载体编码的转基因的表达，以及生理学上的 转基因表达的影响。为此，细胞生物学 核心FaCility保持最先进的荧光设备 检测、最佳过滤器和记录设备， 明场和荧光图像采集，并促进 访问其他医疗中心资源，如组织学， 超微结构和共聚焦设备。此外，工作人员 细胞生物学核心设施在一个广泛的培训， 各种细胞学和组织学技术，并将致力于 时间和资源，使这些资产提供给 参与项目和试点。本核心基金的目标 以及与该计划相关的其他核心设施 项目将在整个研究过程中得以实现 奋进大于各部分的总和。

This Program Project represents a cohesive group of laboratories and investigators that share common goals and strategies aimed at transferring genes to progenitor and differentiated cells. These laboratories also share a need for several techniques such as the creation of gene transfer vectors and the analysis of data generated by gene transfer studies. The Cell Biology Core Facility aims to provide this group of investigators with a variety of imaging and detection methods to show interaction of vectors with target cells, expression of vector-encoded transgenes, and the physiological impact of transgene expression. Toward this end, the Cell Biology Core FaCility maintains state-of-the-art equipment for fluorescence detection, optimal filters and documentation equipment for brightfield and fluorescence image acquisition, and facilitated access to additional medical Center resources such as histological, ultrastructural, and con focal facilities. Furthermore, the staff of the Cell Biology Core Facility has extensive training in a variety of cytological and histological techniques and will dedicate time and resources to make those assets available to the participating Projects and Pilots. The goal of this Core Facility as well as the other core facilities associated with the Program Project will be realized in making the whole of this research endeavor greater than the sum of its parts.