CORE-- NEUROPATHOLOGY

加州大学戴维斯分校阿尔茨海默病中心神经病理学核心的总体目标是确定生活中痴呆症的原因，并将生活中获得的发现（如临床诊断、认知功能测量和神经影像学）与神经病理学基础联系起来。主要目标是获得经纵向队列临床评估的ADC患者和对照组的脑尸检，描述和诊断尸检中发现的所有脑病变，特别是与AD病理和脑血管病理相关的变化，将这些神经病理诊断与每个患者的临床和神经影像学结果相关联，并为我们自己和其他机构的研究人员提供保存完好的尸检脑组织。神经病理学核心将继续以往与临床核心密切合作的做法，以确保对感兴趣的受试者进行尸检。这包括那些在纵向队列中登记的个体，他们特别可能也表现出与脑血管疾病（CVD）相关的病理变化。神经病理学核心已经开发并将继续改进方法，绘制死后心血管疾病的位置和严重程度，期望这种精确的分析水平将使我们能够提高划分阿尔茨海默病和脑血管变化对导致痴呆症的相对重要性的能力。除了这些CVD的测量外，核心将使用标准化标准测量AD和路易体病理，并将寻求仔细描述其他和不寻常的痴呆原因的病理结果。Core的其他重要特点是定期召开临床病理学会议，在出现混合原因时采用分层方法诊断痴呆症，大量记录良好的组织样本清单，以及与生物统计学和数据管理Core完全集成的详细数据库。

The UC Davis Alzheimer's Disease Center Neuropathology Core has its overall goal to define the cause of dementia during life and to relate findings obtained during life, such as clinical diagnoses, cognitive function measurements, and neuroimaging to neuropathological substrates. The major goals are to obtain brain autopsies in ADC patients and controls that have been clinically evaluated in the longitudinal cohort, describe and diagnoses all brain lesions found at autopsy, especially changes related to AD pathology and cerebrovascular pathology, correlate these neuropathological diagnoses with the clinical and neuroimaging findings in each patient, and offer well-preserved autopsy brain tissues to research workers in our own and other institutions. The Neuropathology Core will continue the previous practice of working closely with the Clinical Core to ensure that autopsies are obtained on subjects of interest. This includes those individuals enrolled in the Longitudinal Cohort who are particularly likely to also show pathological changes related to cerebrovascular disease (CVD). The Neuropathology Core has developed, and will continue to refine, methods to chart the location and severity of CVD post mortem in the expectation that this precise level of analysis will permit us to improve our ability to partition the relative importance of Alzheimer and cerebrovascular changes to causing the dementia. In addition to these measurements of CVD the core will make measurements of AD and Lewy body pathology using standardized criteria, and will seek to carefully describe the pathological findings in other and unusual causes of dementia. Other important features of the Core are regular clinicopathological conferences, a hierarchical approach to dementia diagnosis when mixed causes are present, a large and well-documented inventory of tissue samples, and a detailed database that is fully integrated with the Biostatistics and Data Management Core.