CORE--BIOSTATISTICS AND DATA MANAGEMENT CORE

我们建议在精神分裂症研究中建立一个精神健康临床研究中心（MHCRC），以取代我们目前的发展中临床研究中心（DCRC）。本节是对MHCRC提案的介绍，也是对五个核心之一，即行政、生物统计和数据管理核心的说明。我们的发展资源中心已成立三年半。在这段时间里，我们把注意力集中在我们最初的目标上，即研究遗传和表观遗传（或环境风险）因素在精神分裂症病因学中的作用。我们还实现了我们的另一个原始目标，并为我们的中心建立了一个重要的神经影像组件。最后，我们已经建立了诊断，现象学，神经免疫学，神经病理学和分子生物学的优势。我们相信，我们现在处于一个很好的位置，将神经影像学和神经生物学研究与精神分裂症的遗传学和流行病学联系起来。通过这种方式，我们希望进行系统的观察，建立可能的病因学因素发生在产前生活和他们的特定关系，生物异常的成年人谁发展精神分裂症。拟议的MHCRC将有五个核心：1）行政，生物统计和数据管理; 2）诊断和治疗研究核心（DTRC）; 3）神经发育和遗传流行病学研究核心（NGRC）; 4）脑成像研究核心（BIRC）;和5）基因组学和神经生物学研究核心（GNRC）。每个核心将负责支持中心范围内的关键需求，并开展针对核心的研究。其中许多功能需要MHCRC的支持，包括提供标准化的研究质量诊断和评估，可用于跨项目;能够保持患者在无药物状态，并招募药物初治受试者;维持几个大的出生队列;并提供最先进的神经成像和实验室设施。行政、生物统计和数据管理核心将：1）为拟议的MHCRC提供总体指导和协调; 2）提供数据管理服务和中央数据库; 3）提供生物统计和研究设计咨询和指导; 4）为广泛的学科提供培训机会;以及5）通过协调纽约州立精神病学研究所/哥伦比亚大学站点和Creedmoor精神病学中心站点之间的研究，继续将学术研究带到公共精神病学环境中。

We are proposing the creation of a Mental Health Clinical Research Center (MHCRC) in Schizophrenia Studies to replace our current Developing Clinical Research Center (DCRC). This section serves as an introduction to the MHCRC proposal and as a description of one of the five cores, the Administrative, Biostatistical and Data Management Core. Our DCRC has now been in place for three and one half years. In that time we have focused our attention on our original aim, to examine the contributions of genetic and epigenetic (or environmental risk) factors in schizophrenia etiology. We have also met another of our original goals and established a significant neuroimaging component to our Center. Finally, we have established strengths in diagnosis, phenomenology, neuroimmunology, neuropathology, and molecular biology. We believe that are now in an excellent position to link neuroimaging and neurobiological research to genetics and epidemiology of schizophrenia. In this way, we hope to make systematic observations that establish both likely etiological factors occurring from prenatal life and their specific relationship to biological abnormalities in adults who develop schizophrenia. The proposed MHCRC will have five cores: 1) Administrative, Biostatistical and Data Management; 2) Diagnosis and Treatment Research Core (DTRC); 3) Neurodevelopmental and Genetic Epidemiology Research Core (NGRC); 4) Brain Imaging Research Core (BIRC); and 5) Genomics and Neurobiology Research Core (GNRC). Each core will be responsible for supporting critical Center-wide needs and for conducting Core-specific research. Many of these functions require MHCRC support including the provision of standardized research-quality diagnosis and assessments that can be used across projects; the ability to maintain patients in a medication-free state and to recruit medication-naive subjects; the maintenance of several large birth cohorts; and the provision of state-of-the-art neuroimaging and laboratory facilities. The Administrative, Biostatistical and Data Management Core will 1) provide overall directions and coordination for the proposed MHCRC; 2) provide data management services and a central database; 3) provide biostatistical and research design consultation and guidance; 4) maintain training opportunities for a broad range of disciplines; and 5) continue to bring academic research to the public psychiatry setting by coordinating research between the New York State Psychiatric Institute/Columbia University site and the Creedmoor Psychiatric Center site.