DEVELOPING VIRTUAL COLONOSCOPY FOR CANCER SCREENING

描述（来自申请人摘要的逐字）：结肠直肠癌是 第三大最常见的癌症和第二大死亡原因 癌症在美国。它通常在晚期被诊断出来， 在病人出现症状后，解释了它的高死亡率。 由于大多数癌症都是由息肉引起的，在5到15年的恶性周期内， 转化，筛查计划，以检测小于1厘米的小息肉， 直径一直在提倡。不幸的是，大多数人并没有遵循这一点。 建议.这个项目的健康相关性 增加愿意参加筛查计划的人数， 使用一种方便的几乎无风险的方法 虚拟结肠镜是一种新的程序，其中的计算机断层扫描图像， 获取患者的腹部，并使用计算机可视化系统来 在构建的结肠3D模型内进行虚拟导航。那个女人 该提案的长期目标是开发虚拟结肠镜检查， 准确、经济、无创、舒适的大屏幕技术 人口的部分。 为了进一步发展这项技术，本提案的具体目标是：（1） 开发使用肠道准备方法的电子结肠清洗， 计算机分割技术，（2）研究生成 飞行路径和导航环境，以及纠正结肠塌陷，（3） 优化自动、实时体绘制， 用于分析可疑异常的控制，以及（4）确定 与光学结肠镜相比，虚拟结肠镜的准确性。 研究设计和方法将包括评估以下能力： 电子清洁结肠在正常的，大学年龄的志愿者， 连续几天进行虚拟结肠镜检查;可行性 将技术带到一个容易获得的环境中， 结肠导航的处理速度和质量;以及 实时体绘制算法的准确性，通过比较虚拟和 使用改良结肠在同一患者中进行光学结肠镜息肉检测 制备粪便/液体标记口服造影剂溶液。

DESCRIPTION (Verbatim from the Applicant's Abstract): Colorectal carcinoma is the third most commonly diagnosed cancer and the second leading cause of death from cancer in the United States. Often it is diagnosed at an advanced stage, after the patient has developed symptoms, explaining its high mortality rate. Since most cancers arise from polyps over a 5 to 15 year period of malignant transformation, screening programs to detect small polyps less than 1 cm in diameter have been advocated. Unfortunately most people do not follow this recommendations. The health relatedness of this project is to dramatically increase the number of people willing to participate in screening programs by using a convenient, nearly risk-free procedure. Virtual colonoscopy is a new procedure in which computed tomographic images of the patient's abdomen are taken and a computer visualization system is used to virtually navigate within a constructed 3-D model of the colon. The broad, long-term objective of this proposal is to develop virtual colonoscopy as an accurate7 costeffective, non-invasive, comfortable technique to screen large segments of the population. To further advance this technology, the specific aims of this proposal are: (1) to develop electronic colon cleansing using bowel preparation methods and computer segmentation techniques, (2) to investigate means for generating a flight-path and a navigation environment, and correcting colon collapse, (3) to optimize automatic, real-time volume rendering with various interactive controls for analysis of suspected abnormalities, and (4) to determine the accuracy of virtual colonoscopy compared to optical colonoscopy. The research design and methodology will include evaluating the ability to electronically clean the colon in normal, college-aged volunteers by looking at virtual colonoscopy procedures performed on consecutive days; the feasibility of bringing the technology to a readily accessible environment by documenting the processing speed and quality of produced navigation through the colon; and the accuracy of real-time volume-rendering algorithms by comparing virtual and optical colonoscopy polyp detection in the same patient using a modified colon preparation with stool/fluid labeling oral contrast solutions.