Effects of intestinal inflammation on functioning of enteric neurons: from animal models to humans

克罗恩病和溃疡性结肠炎是两种令人虚弱的疾病，被称为炎症性肠病(IBD)，影响着超过61,000名澳大利亚人。目前还没有治愈IBD的方法。所有的肠道功能都是由肠壁中的肠神经元控制的。炎症会导致这些神经元的损伤和死亡，从而导致肠道功能障碍。这是第一次确定受炎症影响的人类肠道神经元的类别的研究。这项研究将测试几个治疗IBD的潜在新靶点。

Crohn’s disease and ulcerative colitis, two debilitating conditions known as Inflammatory Bowel Disease (IBD), affect more than 61,000 Australians. There is no cure for IBD. All gut functions are controlled by enteric neurons in the gut wall. Inflammation causes damage and death of these neurons leading to gut dysfunctions. This is the first study defining the classes of human enteric neurons affected by inflammation. This study will test several potential new targets for the treatment of IBD.