OTOACOUSTIC EMISSION COCHLEOGRAPHY

描述：拟议的实验的主要目标是 失真产物耳声发射(DPOAEs)有待进一步研究 影响该领域根本的完全特定的问题 对几种相对较新发展的措施的理解 抑制和潜伏期。另一个目标是开始识别 与DPOAE产生过程的解剖对应。具体地说，一个 明确的目标是确定抑制-调谐曲线是否提供了一种测量 或提示DPOAE的发生部位(S)。另一个 具体目的是确定基础外毛细胞的贡献 (OHC)在小型实验动物和人类中观察到 Q位以上DPOAE的抑制和增强。一个模糊的目标是 确定是否系统地引起DPOAE潜伏期测量的改变 反映耳蜗术后滤过的改变和/或耳蜗肌的 DPOAE-生成过程。最后一个具体目标是开始确定 OFIC的立体纤毛的地位有助于 高级DPOAE生成器，如果更改的抑制调谐显示 一些实验动物在暴露于噪音后与 更多位于基底区的正常毛细胞。拟议的研究将是 使用人和实验室兔以并行方式执行 研究对象。基本的实验计划是进行批判性的比较 在正常耳朵和病理耳朵中产生的DPOAE之间的差异 暂时或永久地因接触过多的声音或 耳毒性药物速尿的使用。评选结果 计划中的实验将有助于我们的知识库关于 生产DPOAE的基本过程，DPOAE的身份 承诺在临床上有用的措施，以及DPOAE的相关性 在实验室哺乳动物中的世代与在人类中的世代相同。

DESCRIPTION: The primary goal of the proposed experiments on distortion-produc otoacoustic emissions (DPOAEs) is to investigate more completely particular issues that impact the field's fundamental understanding of several relatively recently developed measures of suppression and latency. An additional aim is t begin to identify the anatomical counterparts of the DPOAE-generation process. Specifically, one explicit goal is to determine if suppression-tuning curves provide a measure of cochlear trauma, or indication of the DPOAE generation site(s). Another specific aim is to determine the contribution that basal oute hair cells (OHCs) make to the observations in small laboratory animals and humans of suppression and enhancement of the DPOAE above the Q place. A furthe aim is to establish if systematically induced changes in DPOAE latency measure reflect alterations in cochlear filtering and/or build-up of the DPOAE-generation process. A final specific aim is to begin to determine if the status of the OFIC's stereocilia contribute to the viability of high-level DPOAE generator, and if the altered suppression tuning exhibited by some experimental animals following noise exposure is associated with more basally located regions of normal OHCs. The proposed studies will be performed in a parallel manner using both human and laboratory-rabbit subjects. The basic experimental plan is to make critical comparisons between DPOAEs generated in normal and pathological ears that have been temporarily or permanently altered by either exposure to excessive sounds or the administration of the ototoxic drug furosemide. The results of the planned experiments will contribute to out knowledge base concerning the basic processes underlying the production of DPOAEs, the identity of DPOAE measures that promise to be clinically useful, and the relevance of DPOAE generation in laboratory mammals to that in humans.