Pediatric Endocrinology Research Training Program

描述（由申请人提供）：该计划的目标是培养 在遗传学，发病机制， 儿科内分泌疾病（包括糖尿病）的评估和管理 和肥胖。代谢、免疫和遗传方面的培训， 将强调学科所涵盖的疾病。除了有 传统的儿科内分泌学，分子生物学， 分子遗传学和基因治疗将特色，因为这些新的 儿童内分泌疾病的诊断和治疗将 必须由该领域未来的领导者掌握。未来的收益 了解儿科内分泌疾病将通过一个 基础科学和临床科学的整合以及 来自许多不同学科的个人。国家科学家库 能够在儿科内分泌学-糖尿病学方面取得新的进展， 严格限制。威尔-康奈尔大学的项目有着出色的记录， 培训这些领导人;然而，实验室有足够的保护时间 对受训人员的研究长期受到限制。儿科 本文所述的内分泌糖尿病训练计划（Pediatrap）是基于 基础和临床科学家的合作指导， 洛克菲勒威尔-康奈尔医学院 纪念斯隆-凯特琳大学及其附属哥伦比亚学院 内科医生和外科医生。两名已完成住院医师培训的MD学员， 第一年的儿科内分泌学专科培训将采取 每年参加两年的培训合格申请人 将通过内分泌学会和其他机构寻求来自少数民族的 以少数族裔为招聘目标的组织。对于每个学员， 将是一个必要的核心课程课程和出席研讨会， 研讨会，由导师指导实验室培训，积极资助 能够支持受训者研究经验的研究项目 在两年的时间里。一个专家咨询学院，在广泛的 相关学科将参加讲座系列和补充 适合受训者研究兴趣的实验室培训。一 尊敬的执行委员会将确保连贯一致和重点突出地使用 三机构综合体以及正在进行的方案评估。的 这项研究培训计划的优势是深度和广度， 教师的专业知识和培训经验， 儿科GCRC，一群杰出的咨询教师的承诺， 教师作为研究导师所取得的成功， 在各种教职员工和学员中， 四个优秀研究机构的资源。国家需要 儿科临床知识的实验室培训 内分泌学家-糖尿病学家是急性的。这种内分泌的增长 如肥胖症、胰岛素抵抗综合征、糖尿病、高血压、 免疫介导的内分泌疾病、肾上腺和卵巢遗传疾病 怨恨一个挑战，这个应用程序被设计来满足。

DESCRIPTION (provided by applicant): The goal of this program is to train highly qualified young pediatricians in the genetics, pathogenesis, evaluation, and management of pediatric endocrine disorders including diabetes and obesity. Training in metabolic, immunological and genetic aspects of the diseases encompassed by the discipline will be emphasized. In addition to the traditional core of training in Pediatric Endocrinology, molecular biology, molecular genetics and gene therapy will be featured, since these new dimensions for diagnosis and treatment of endocrine diseases of childhood will have to be mastered by future leaders of the field. Future gains in the understanding of pediatric endocrine diseases will come about through an integration of basic and clinical sciences and the collaboration of individuals from many and diverse disciplines. The national pool of scientists capable of making the next advances in pediatric endocrinology-diabetology is severely limited. The program at Weill-Cornell has an excellent record of training such leaders; however, sufficient protected time for laboratory research for trainees has been chronically constrained. The Pediatric Endocrine-Diabetes Training Program (Pediatrap) described herein is based on the collaborative mentorship of basic and clinical scientists at the tri-institutional complex of Well-Cornell College of Medicine, Rockefeller University, Memorial Sloan-Kettering, and affiliated Columbia College of Physicians & Surgeons. Two MD trainees who have completed residency and the first year of subspecialty training in Pediatric Endocrinology will be taken into the program for two years of training each year. Qualified applicants from ethnic minorities will be sought through the Endocrine Society and other organizations with minority recruitment objectives. For each trainee, there will be a required core course curriculum and attendance at seminars and symposia, with mentored laboratory training by preceptors with active funded research programs who can support the trainee's investigational experience over a 2-year period. A consulting faculty of experts in a wide range of related disciplines will participate in the lecture series and supplementary laboratory training appropriate to the trainee's research interests. A distinguished executive committee will ensure cohesive and focused use of the tri-institutional complex as well as ongoing evaluation of the program. The strengths of this research training program are the depth and breadth of expertise and training experience of the preceptors, the availability of a pediatric GCRC, the commitment of a distinguished group of consulting faculty, the demonstrated success of the faculty as research mentors, the interactions among the various faculty members and trainees, and the prodigious research resources of four outstanding research institutions. The national need for laboratory training of clinically informed pediatric endocrinologists-diabetologists is acute. The growth in such endocrine disorders as obesity, insulin resistance syndromes, diabetes, hypertension, immune-mediated endocrine diseases, and adrenal and ovarian genetic disorders resents a challenge, which this application is designed to meet.