CARDIOVASCULAR RESEARCH TRAINING

在这个修订后的建议中，我们提出了一个心血管训练计划，以训练计划，以培养医学博士。和博士博士后研究员发展必要的基础科学调查技能，调查心血管疾病发展的病理生理学和机制。一个统一的研究方法是通过高度互动的基础科学研究人员小组将基础实验室科学与临床领域的信息尽可能地整合在一起，重点关注四个核心领域，包括：1）膜蛋白生物化学，2）血管生物学，3）发育生物学和（4）心脏电生理学。该计划最初于1977年获得资助，并已进行修订，以创建一个培训环境，在该环境中，医学博士和博士在相同的基础实验室接受博士后培训，以促进基础科学家和临床医生之间的互动，并弥合基础知识和临床应用之间的鸿沟。在这项资助的支持下，我们打算为四类研究员提供基础科学培训：希望至少在基础实验室工作两年的医学博士; 2）作为ABIM新研究途径（以前的临床研究者途径）的一部分，在基础实验室工作三年; 3）在研究项目中获得博士学位五年; 4）希望在基础实验室工作至少三年的博士后。参与的基础科学部门包括：1）生理学和生物物理学，2）生物化学和分子生物学。参加的还有威尔斯儿科研究中心和电气工程系。这个高度互动和多学科的计划汇集了医生研究人员和基础科学家和基础科学家，他们在了解心血管过程的生理学和病理生理学方面有着共同的兴趣。此外，该计划非常适合有效地招募代表性不足的少数民族。我们建议每年培养3名博士后研究员，为期2年，作为这笔赠款的一部分。

In this revised proposal, we present a cardiovascular training program to training program to train M.D. and Ph.D. postdoctoral Fellows to develop the necessary basic science investigator skills to investigate the pathophysiology and mechanisms underlying the development of cardiovascular disease. A unifying research approach is to integrate information from the basic bench science with clinical areas as much as possible by a highly interactive group of basic science investigators focused on four core areas including: 1) membrane protein biochemistry, 2) vascular biology, 3) developmental biology and (4) cardiac electrophysiology. The program was funded initially in 1977 and has been revised to create a training environment in which both M.D.s and Ph.D.s receive postdoctoral training in the same basic laboratories to foster interactions between basic scientists and clinicians, and bridge the chasm between fundamental knowledge and clinical application. Under support from this grant, it is our intent to offer basic science training to four categories of Fellows: M.D.s who wish to spend at least 1) two years in a basic lab; 2) three years in a basic lab as part of the ABIM's new research pathways (formerly the Clinical Investigator Pathway); 3) five years in a research program to obtain a Ph.D.; and 4) postdoctoral Ph.D.s who wish to spend at least three years in a basic lab. Participating basic science departments include: 1) Physiology and Biophysics, 2) Biochemistry and Molecular Biology. Also participating is the Wells Center for Pediatric Research and the Department of Electrical Engineering. This highly interactive and multi-disciplinary program brings together physician investigators and basic scientists and basic scientists who share common interests in understanding the physiology and pathophysiology of cardiovascular processes. In addition, the program is ideally suited to effectively recruit under-represented minorities. We proposed to train 3 postdoctoral Fellows each year for 2 years as part of this grant.