Effects of parvalbumin up-regulation on Ca2+ handling and contractile properties in skeletal muscle from aged mice

衰老伴随着肌肉功能的丧失，这可能是由于与年龄相关的钙调节损伤。本项目旨在通过基因转移增强钙缓冲能力，改善老年动物肌肉中的钙调节。这是否能改善老年人损伤后的肌肉功能和肌肉再生将被评估。来自这个项目的信息可能会导致新策略的发展，以对抗随着年龄增长而丧失的肌肉功能。

Ageing is accompanied by a loss of muscle function that may be due to an ageing-related impairment of calcium regulation. This project aims to improve calcium regulation in muscles of aged animals by enhancing the calcium buffering capacity via gene transfer. Whether this improves muscle function and muscle regeneration following injury in the aged will be assessed. Information from this project could lead to development of novel strategies to combat the loss of muscle function with ageing.