LEUKOCYTE TRAFFICKING IN SIV INFECTED RHESUS MONKEYS

在晚期SIV感染猕猴中，慢病毒感染 SIV特异性浸润液中有大量的白细胞，但很少 在与机会主义相关的炎症部位检测到 感染，如分枝杆菌病、SV40和弓形虫病或在 完全弗氏佐剂(CFA)诱导的皮肤肉芽肿驳斥 HIV/SIV感染过程中机会性感染的理论 作为慢病毒感染细胞招募的刺激 然而，在急性SIV感染期间，我们偶尔观察到 具有与肺炎相关的SIV阳性白细胞的动物-和 CFA诱导的肉芽肿我们还描述了病毒阳性细胞 与肺肉芽肿相关的细胞浸润 由短尾猴(Macaca)中的四甲虫感染 在急性SIV感染期间，我们的假设是 感染SIV的白细胞能够运输到炎症部位 在感染早期，但在疾病晚期失去这种能力

In terminal SIV infection in macaques, lentivirus-infected leukocytes are numerous in SIV-specific infiltrates yet are rarely detected at inflammatory sites associated with opportunistic infections such as mycobacteriosis, SV40, and toxoplasmosis or in complete Freund's adjuvant (CFA)-induced skin granulomas This refutes the theory that opportunistic infections during HIV/SIV infection serve as a stimulus for the recruitment of lentivirus-infected cells However, during acute SIV-infection we have observed occasional animals with SIV-positive leukocytes associated with Pneumonyssus- and CFA-induced granulomas We have also described virus-positive cells in the cellular infiltrates associated with pulmonary granulomas induced by tetrathyridia of Mesocestoides in a pigtailed macaque (Macaca nemestrina) during acute SIV infection Our hypothesis is that SIV-infected leukocytes are able to traffic to inflammatory sites early in infection, but lose this ability late in dise ase