MBRS PROGRAM

这项提案要求继续支持非常成功的 南科罗拉多大学(USC)的MBRS项目。目标 这项计划的目的是增加少数民族学生的数量 取得生物医学高级学位，并加强 南加州大学教职员工和学生的研究机会 为广大少数民族社区和学生提供服务的机构 人口。把学生培养成多产的、成熟的和 伦理科学家是首要目标。为了实现这些目标， 这份提案描述了八个研究项目，涉及以下领域 生物、化学、心理学和人类表现研究。 这八个研究项目包括两个化学项目，两个生物学项目， 在生物化学和人类行为研究中各有一名。其中之一 生物学项目调查了M1金属的作用- 酵母细胞生理学中的氨基肽酶基因。第二生物学 项目检查子宫蛋白酶活性对胚胎的影响 植入。这个生物化学项目试图描述和描述 确定真菌酸性磷酸酶的功能 与哺乳动物抗酒石酸的高度同源性 在细胞性白血病中过度表达的酸性磷酸酶。一 化学项目探索药物化合物的合成路线 通过氟化反应。第二个化学课题的目标 是通过设计有选择性的和 用于层析分离的特殊材料 制药公司。其中一个心理学项目调查了 神经肽及其受体在血管紧张素转换酶调控中的作用 酒精动物模型中的自愿酒精偏好 消费。第二个心理学项目考察了两者之间的关系 大鼠的食盐食欲和神经生理变化之间的关系。 人类表现研究项目考察了心理和心理状态 有助于维持体力活动的社会因素 在以西班牙裔教堂为基础的人口中的健康。的多样性 这些项目和教职研究人员预计将吸引和 积极让学生参与富有成效的研究体验，如 为生物医学研究生课程做准备。

This proposal requests continued support for the highly successful MBRS Program at the University of Southern Colorado (USC). The goals of this program are to increase the number of minority students attaining advanced degrees in the biomedical sciences and to enhance research opportunities for faculty and students at USC, an institution that serves a large minority community and student population. The development of students into productive, mature, and ethical scientists is a primary objective. To achieve these goals, this proposal describes eight research projects spanning the areas of biology, chemistry, psychology, and human performance studies. The eight research projects include two in chemistry, two in biology, and one each in biochemistry and human performance studies. One of the biology projects investigates the role of the M1 metallo- aminopeptidase gene in yeast cell physiology. The second biology project examines the effect of uterine proteinase activity on embryo implantation. The biochemistry project seeks to characterize and determine the function of fungal acid phosphatases that exhibit a high degree of sequence homology to the mammalian tartrate-resistant acid phosphatases that are overly expressed in cell leukemia. One chemistry project explores synthetic routes to medicinal compounds via fluorination reactions. The second chemistry project's objective is to advance biomedical research through the design of selective and specific materials for chromatographic separations of pharmaceuticals. One of the psychology projects investigates the function of neuropeptides and their receptors in the control of voluntary alcohol preferences in an animal model of ethanol consumption. The second psychology project examines the relationship between salt appetite and neural physiological changes in the rat. The human performance studies project examines the psychological and social factors that contribute to maintenance of physical activities and health in a Hispanic church-based population. The diversity of the projects and the faculty researchers is expected to attract and actively engage students in productive research experiences as preparation for graduate biomedical programs.