Hybrid Supramolecules Assembled Using H-Bonds and metals

描述：(申请人提供)：自然界使用氢键 以及无处不在的金属-配体相互作用，将蛋白质结合在一起 高阶结构。这种方法在合成化学中很少使用。 并且从未被用来产生离散的主客体复合体。具体的 这个项目的目标是使用基于对称的方法，类似于 用于制造金属配体超分子团簇，组装纳米级 同时使用氢键和金属配体的含空位团簇 将组件保持在一起的交互。大自然欣赏自然的力量 利用一个生物分子中的金属配位和氢键，这 该提案寻求在准备合成规模上通过耦合来模仿这一主题 一种众所周知的金属螯合模块，可实现自互补氢键 单个分子内的组件。同时配合螯合剂到一个 金属离子与形成的自互补氢键会导致 高对称性、含空穴的二聚体组件的自组装 由12个金属配位键和12个氢键组成。这些混合纳米级 将研究组件以了解：(1)金属配位如何在 杂化分子-分子内复合体将影响客体的亲和力 包裹体，(2)超分子的“折叠”或整体拓扑 络合物受金属配位和/或氢键的影响，以及(3) 金属配位之间是否存在协同或协同效应 以及组装这种合成类似物时的氢键。此外, 杂化超分子络合物的成功合成将提供一个证据 建议的设计策略的原则性，并允许合成新的 利用这些纳米尺度产生的主客体化学的集群 复合体。

DESCRIPTION: (provided by applicant): The natural world uses hydrogen bonding and metal-ligand interactions ubiquitously to hold proteins together into higher order structures. This approach is rarely used in synthetic chemistry and has never been used to generate discrete host-guest complexes. The specific goals for this project are to use a symmetry-based approach, similar to that employed to make metal-ligand supramolecular clusters, to assemble nanoscale cavity-containing clusters using both hydrogen bonding and metal-ligand interactions to hold the assembly together. Nature appreciates the power of using metal coordination and hydrogen bonding within one bio-molecule, this proposal seeks to mimic this motif on a preparative synthetic scale by coupling a well-known metal chelating module to a self-complementary hydrogen bonding module within a single molecule. Simultaneous coordination of the chelator to a metal ion and formation of the self-complementary hydrogen bonds will result in the self-assembly of a high-symmetry, cavity-containing, dimeric assembly composed of 12 metal-ligand bonds and 12 hydrogen bonds. These hybrid nanoscale assemblies will be studied to understand: (1) how metal coordination in a hybrid molecule-within-molecule complex will affect the affinity of guest inclusion, (2) how the "folding" or overall topology of the supramolecular complex is influenced by metal coordination and/or hydrogen bonding, and (3) whether there is a cooperative or synergistic effect between metal-coordination and hydrogen bonding when assembling such synthetic analogues. In addition, successful synthesis of a hybrid supramolecular complex would provide a proof of principle to the proposed design strategy and allow synthesis of new clusters to exploit the host-guest chemistry generated by these nanoscale complexes.