Identifying target regions for Neurofeedback treatment of auditory hallucinations using EEG of experimentally induced and pathological hallucinations

精神分裂症的听觉言语幻觉（AVH）模型将其视为内部言语错误归因于外部来源。一些功能磁共振成像研究表明，在AVH期间，辅助运动区（SMA）的活动减少。然而，fMRI的时间分辨率有限，而fMRI病例对照研究中的脑症状相关性存在潜在的混淆。本研究将改进的脑电图时间分辨率与症状建模方法和患者研究相结合，以描述SMA与AVH的关系。研究（一）：催眠反应个体在AVH前、中、后的脑电图测量对AVH的建议。我们检验了脑电图指数在AVH期间选择性地减少额颞叶导联的假设。我们认为这表明SMA活性较低以及与语言生成区域的功能耦合是AVH的近似脑机制。研究（ii）：我们将此设计扩展到慢性AVH患者，验证相同的假设。

Models of auditory verbal hallucinations (AVH) in schizophrenia view them as inner speech misattributed to an external source. Several fMRI studies implicate reduced activity of supplementary motor area (SMA) during AVH. However, fMRI has limited temporal resolution, while brain-symptom correlations in fMRI case-control studies have potential confounds. This study combines the improved temporal resolution of EEG with a symptom modelling approach and patient studies to delineate the relationship of SMA to AVH. Study (i): suggestions for AVH in hypnotically responsive individuals with EEG measurement before, during, and after AVH. We test the hypothesis that EEG indices are selectively reduced in frontotemporal leads during AVH. We interpret this as indicating lower activity of SMA and functional coupling with language generation regions as the proximate brain mechanism of AVH. Study (ii): we extend this design to patients with chronic AVH, testing the same hypothesis.