Sniff Magnitude Ratio as a Measure of Olfactory Acuity

描述（由申请人提供）：脂肪损失是一个健康和安全问题 为数百万美国人。嗅觉功能的评估不是常规的 进行，因为快速，廉价和强大的嗅觉测试是不可能的。 available.我们的SBTR第一阶段赠款证明了一个新的测试的可行性， 嗅觉功能嗅觉强度测试测试表现良好， 与标准测试相比，成人的可靠性和有效性研究，以及 在对儿童的测试中证明其优于UPSIT上级。因为闻起来 测试是基于对恶臭刺激的嗅闻的反射式减少，其 假设它将比标准测试具有优势， 丰富的认知、记忆和语言技能。SBIR第二阶段 本申请旨在通过（1）改善气味， 递送和嗅探测量设备和协议，（2）降低成本， 试验器械，（3）证明试验在临床中的实用性，以及（4） 提供了强有力的证据，证明了检验在人群中的优势 他们已经证明难以或耗时的评估与现有的嗅觉 敏锐度测试。

DESCRIPTION (provided by applicant): Smell loss is a health and safety problem for millions of Americans. Assessment of smell function is not routinely performed because a rapid, inexpensive and robust test of olfaction is not available. Our SBTR Phase I grant demonstrated the feasibility of a new test of olfactory function, the sniff magnitude test. The test performed well in reliability and validity studies with adults as compared to standard tests, and proved to be superior to the UPSIT in tests with children. Because the sniff test is based on reflex-like reduction of sniffing to a malodorous stimulus, it is hypothesized that it will have advantages over standard tests that require substantial cognitive, memory and language skills. This SBIR Phase II application aims to enhance the sniff magnitude test by (1) improving the odor delivery and sniff measurement equipment and protocol, (2) reducing the cost of the test device, (3) demonstrate the utility of the test in the clinic, and (4) providing robust demonstrations of the advantages of the test with populations who have proved difficult or time consuming to evaluate with existing olfactory acuity tests.