BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

本计划项目拨款提案寻求继续支持 研究旨在更全面地了解和 磁化率和其他本征磁化率的新应用 提供体内生理功能的核磁共振对比机制 信息。这项研究探索了两者之间的关系 微观生物区划与宏观 核磁共振图像对比度。尽管在以下方面取得了很大进展 了解这些现象，因为它们与测量 血液容量和铁的生物化学，许多悬而未决的问题， 特别是关于灌流，氧气消耗，和 瞄准的有效性仍然存在。协调调查…… 提供这些效果是为了提高MR成像的利用率 在各种器官系统和病理状态下，包括 癌症和冠状动脉疾病。实时的可用性 作为研究这些问题的工具的回波平面成像 继续提供新的机遇和科学挑战。 这项建议分为四个研究项目，它们共享 核心资源和方法有相当大的重叠 和人员，以便进行建设性的互动。四个 项目有：1)探索核磁共振成像在肿瘤血管生成中的应用 磁化率和其他固有的核磁共振对比机制 肿瘤新生血管的体内评估及其对治疗的反应 抗血管生成治疗；2)心肌的核磁共振研究 灌注“涉及到心肌血流储备的测量 在动物模型和患者中使用固有的T1和T2*对比 机理；3)“核磁共振成像中的磁化率对比” 在以下几个方面提供理论和实验评估 生物异质性产生可量化的系统 对比度和核磁共振成像过程的细节是 对基础生物学的量化至关重要。4)“核磁共振” 《受体成像》探索新的受体和免疫专一性 氧化铁造影剂在体示征中的应用 癌症。要检验的总体假设包括：1)磁性 磁化率和其他本征核磁共振效应可用于 定量评估血流量、血容量并测量 体内血管大小的密度和2)超顺磁性铁 氧化物颗粒可以靶向肿瘤特异性受体，使 用核磁共振成像进行活体表征。这些项目是 由三个核心实验室、核磁共振设施、核磁共振支持 计算机和技术，以及造影剂核心，并由 管理核心。

This Program Project Grant proposal seeks continued support for research directed toward a more comprehensive understanding and novel applications of magnetic susceptibility and other intrinsic NMR contrast mechanisms that provide in vivo physiological information. This research explores the relationship between microscopic biological compartmentalization and macroscopic NMR image contrast. Though much progress has been made in understanding these phenomena as they pertain to measurements of blood volume and iron biochemistry, many unresolved issues, particularly concerning perfusion, oxygen consumption, and targeting effectiveness remain. A coordinated investigation of these effects is provided to enhance the utilization of MR imaging in a variety of organ systems and pathological states, including cancer and coronary artery disease. The availability of real time echo planar imaging as a tool for the study of these questions continues to offer both new opportunities and scientific challenges. This proposal is divided into four research projects which share Core resources and have considerable overlap of methodologies and personnel to allow for constructive interaction. The four projects are: 1) "NMR Imaging in Tumor Angiogenesis" explores susceptibility and other intrinsic NMR contrast mechanisms for the in vivo assessment of tumor neovascularity and the response to anti-angiogenic therapy; 2) "NMR Studies of Myocardial Perfusion" addresses the measurement of myocardial flow reserve in animal models and patients using intrinsic T1 and T2* contrast mechanisms; 3) "Susceptibility Contrast in NMR Imaging" provides theoretical and experimental assessment in several systems in which biological heterogeneity produces quantifiable contrast and that the specifics of the NMR imaging process are crucial to the quantification of the underlying biology. 4) "NMR Receptor Imaging" explores novel receptor and immunospecific iron oxide contrast agents for the in vivo characterization of cancer. Overall hypotheses to be tested include: 1) that magnetic susceptibility and other intrinsic NMR effects can be used to quantitatively assess blood flow, blood volume and measure the density of vessel size in vivo and 2) that superparamagnetic iron oxide particles can be targeted to tumor specific receptors enabling in vivo characterization with NMR imaging. These projects are supported by three Core laboratories, NMR Facilities, NMR Computer and Technologies, and Contrast Agent Cores, and by an Administrative Core.