核心——有机制剂和分析实验室服务-猫眼课题宝

核心——有机制剂和分析实验室服务

批准号：

6444597

负责人：

KAMAL N TIWARI

金额：

$22.84万

依托单位：

SOUTHERN RESEARCH INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

1986

资助国家：

美国

项目状态：

已结题

起止时间：

1986-04-01 至 2006-01-31

来源：

https://reporter.nih.gov/project-details/6444597

关键词：

analytical chemistry antineoplastics biomedical facility chemical synthesis drug design /synthesis /production high throughput technology nucleoside analog nucleoside triphosphate organic chemicals prodrugs

项目摘要

项目成果

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中文摘要

翻译

申请者描述：(由申请者提供)本次活动的总体目标核心是双重的。主要目标是为更大的拟用中间体和最终产品的规模化合成或再合成由赠款中的所有项目提供。另一个目标是提供一个机制1)为我们的分析服务购买一次性物品用于所有合成有机项目的集团；以及2)用于支付维护维护时间所需的适当百分比仪表处于最佳运行状态。作为第一个目标的一部分，我们将还合成了生物所需的核苷三磷酸酯实验。一开始，我们需要合成两个三磷酸核苷，4(-硫代-阿拉伯-C和2-氯-2)-脱氧-2(-氟腺苷，用于项目16中的作用机理研究。其他核苷将根据需要进行合成。

英文摘要

APPLICANT'S DESCRIPTION: (provided by Applicant) The overall goals of this core are twofold. The main goal is to provide a mechanism for the larger scale synthesis or resynthesis of intermediates and final products to be used by all of the projects in the grant. An additional goal is to provide a mechanism 1) for the purchase of disposable items for our Analytical Services Group to use for all of the synthetic organic projects; and 2) for defraying the appropriate percentage of maintenance time required for keeping our instruments in top operating condition. As part of this first goal, we will also synthesize needed triphosphates of nucleosides for biological experiments. In the beginning, we need to synthesize the triphosphate of two nucleosides, 4(-thio-ara-C and 2-chloro-2(-deoxy-2(-fluoroadenosine, for mechanism of action studies in Project 16. The triphosphates of other nucleosides will be synthesized as needed.

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