21st century truffle production: the application of chemical biology (GANESAN_U17ICASE)

松露是最贵的蘑菇，每磅价值数千美元。它们是块茎属真菌的子实体，由于涉及缓慢而复杂的生命周期，成本较高。这种真菌在植物寄主的根部共生生长，这个过程需要数年的时间才能成熟。这个项目将给你一个独特的机会来进行尖端的分子生物学和化学生物学技术，以提高我们对松露生命周期的理解，并确定改进栽培方法的方法。这将是一个跨学科的项目，结合了微生物学、化学生物学和工业生物技术的各个方面，非常适合有兴趣在完成博士学位后从事科学事业的学生。学术指导Ganesan教授以表观遗传学研究而闻名，也是Karus治疗公司的联合创始人。非学术合作伙伴是菌根系统有限公司，一家将创新和现代科学技术应用于块菌生产的公司。该公司是英国第一家种植松露的公司，在23个国家拥有研究基地，并在现场建立了自己的实验室。

Truffles are the most expensive mushrooms, costing thousands of dollars per pound. They are the fruiting bodies of fungi of the genus Tuber and the high cost is due to the slow and complex life cycle involved. The fungus grows symbiotically on the roots of a plant host in a process that takes years for maturation.This project will give you a unique opportunity to carry out cutting edge molecular biology and chemical biology techniques to improve our understanding of the truffle life cycle and identify methods to improve cultivation methods. This will be an interdisciplinary project combining aspects of microbiology, chemical biology and industrial biotechnology and well suited for students interested in pursuing a scientific career upon completion of the PhD. The academic supervisor Prof. Ganesan is well-known for his research in epigenetics and is co-founder of the company Karus Therapeutics. The non-academic partner is Mycorrhizal Systems Ltd, a company that is applying innovative and modern scientific techniques to truffle production. The company was the first to cultivate truffles in the UK and has research sites in 23 countries and its own laboratory on site.